INT149261

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.45
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Hcn2) plasma membrane (Hcn2) transmembrane transport (Hcn2)
Anatomy Link Frequency
IB4 1
dorsal root ganglion 1
Hcn2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 14 99.36 Very High Very High Very High
Root ganglion neuron 6 98.74 Very High Very High Very High
nociceptor 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 6 98.58 Very High Very High Very High
Nociception 2 69.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neurons lacking HCN-1 or HCN-2 channel isoforms were mostly capsaicin-positive and IB4-negative.
Negative_regulation (lacking) of HCN-2 in IB4 associated with qutenza
1) Confidence 0.11 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18218331 Disease Relevance 0.22 Pain Relevance 0.60
In conclusion, in porcine dorsal root ganglion neurons there is a subset of capsaicin-positive, IB4-negative neurons lacking HCN-1 and/or HCN-2 channel isoforms.
Negative_regulation (lacking) of HCN-2 in dorsal root ganglion associated with ganglion cysts, qutenza and root ganglion neuron
2) Confidence 0.11 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18218331 Disease Relevance 0.23 Pain Relevance 0.56

General Comments

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