INT149267

Context Info Confidence 0.04 First Reported 2004 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 0.73 Pain Relevance 1.16

Anatomy Link Frequency neuronal 1 PIRT (Homo sapiens)

Pain Link Frequency Relevance Heat sodium channel 8 100.00 Analgesic 4 98.00 Calcium channel 4 94.80 tetrodotoxin 2 94.56 qutenza 4 90.12 Central nervous system 3 89.96 Nav1.6 6 75.36 Dismenorea 2 5.00 potassium channel 1 5.00

Disease Link Frequency Relevance Heat Injury 8 100.00 Brain Injury 4 99.64 Blister 2 85.04 Head Trauma 1 25.00 Dysmenorrhea 2 5.00 Emergencies 2 5.00 Breech Presentation 1 5.00 Pre-term Labor 1 5.00 Malignant Neoplastic Disease 1 5.00 Endometriosis (extended) 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We hypothesized that Ca(V)2.3 channels are also modulated by eugenol and investigated its mode of action using the whole-cell patch-clamp technique in a heterologous expression system.

Regulation (modulated) of channels

1) Confidence 0.04 Published 2008 Journal J. Dent. Res. Section Abstract Doc Link 18218839 Disease Relevance 0 Pain Relevance 0.59

Direct effects of mechanical trauma on neuronal Nav channels have not, however, been tested.

Regulation (effects) of channels in neuronal associated with injury and sodium channel

2) Confidence 0.01 Published 2009 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 19657055 Disease Relevance 0.73 Pain Relevance 0.57

-subunit attachment and modulation of the calcium bowl, and their input to regulation of Maxi-K channels during human pregnancy and labour.

Regulation (regulation) of channels

3) Confidence 0.00 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0 Pain Relevance 0

General Comments

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