INT149292

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Context Info
Confidence 0.54
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 6.11
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOTCH1) nucleoplasm (NOTCH1) extracellular region (NOTCH1)
Golgi apparatus (NOTCH1) plasma membrane (NOTCH1) nucleus (NOTCH1)
Anatomy Link Frequency
Notch 3
other parts 1
cleavage 1
nucleus 1
mononuclear cells 1
NOTCH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 9 99.98 Very High Very High Very High
cINOD 15 96.80 Very High Very High Very High
Abeta 9 86.88 High High
tolerance 2 62.28 Quite High
Angina 10 55.16 Quite High
imagery 4 5.00 Very Low Very Low Very Low
aspirin 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Influenza Virus Infection 242 100.00 Very High Very High Very High
Alzheimer's Dementia 6 99.16 Very High Very High Very High
INFLAMMATION 3 96.52 Very High Very High Very High
Respiratory Disease 6 95.96 Very High Very High Very High
Viral Infection 1 88.36 High High
Respiratory Syncytial Virus 42 86.48 High High
Brain Disease 1 86.40 High High
Congenital Anomalies 1 83.04 Quite High
Cancer 203 82.08 Quite High
Necrosis 1 81.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This activated form of Notch1 then translocates to the nucleus and binds with the DNA-binding protein complex CSL (C promoter-binding factor 1, suppressor of hairless and Lag-1), resulting in transactivation of various target genes like hairy enhancer of split-1 (HES-1).
Localization (translocates) of Notch1 in nucleus
1) Confidence 0.54 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 1.01 Pain Relevance 0
Interestingly, some non-steroidal anti-inflammatory drugs (NSAIDs) and other small organic molecules have been found to modulate gamma-secretase and to selectively reduce beta-amyloid(1-42) (Abeta42) levels without affecting Notch cleavage.
Localization (cleavage) of Notch in cleavage associated with inflammation, alzheimer's dementia and cinod
2) Confidence 0.17 Published 2008 Journal Curr Top Med Chem Section Abstract Doc Link 18220933 Disease Relevance 0.89 Pain Relevance 0.55
-secretase and results in the release and translocation of the intracellular domain into the nucleus to execute Notch signaling [49].
Localization (release) of Notch in Notch
3) Confidence 0.06 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0 Pain Relevance 0.08
Th1 and Th2 cytokine secretion was assessed on freshly isolated peripheral blood mononuclear cells (PMBCs) after 4 days of in vitro re-stimulation with recombinant haemagglutinin (rHA) analogous to that of Influenza A/Vietnam/1203/2004(H5N1) (Protein Science Corporation, Meriden, CT) or A/New Caledonia/20/99(H1N1) split inactivated vaccine.
Localization (secretion) of H5N1 in mononuclear cells associated with influenza virus infection and cytokine
4) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605261 Disease Relevance 0.69 Pain Relevance 0.18
The Notch ligands, Jagged 1 & 2 and Delta1 (D1) to Delta3 (D3), induce the release of the Notch intracellular (Notch-IC) domain via enzymatic proteolytic cleavage by ?
Localization (release) of Notch in Notch
5) Confidence 0.06 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC2958340 Disease Relevance 0.59 Pain Relevance 0.13
The Notch ligands, Jagged 1 & 2 and Delta1 (D1) to Delta3 (D3), induce the release of the Notch intracellular (Notch-IC) domain via enzymatic proteolytic cleavage by ?
Localization (release) of Notch in Notch
6) Confidence 0.06 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC2958340 Disease Relevance 0.59 Pain Relevance 0.13
Although the 2009 influenza pandemic caused significant concern in Guatemala and helped to increase recognition of influenza as an important public health issue, the data we have presented here suggest that in Guatemala, the clinical presentation of pH1N1 was similar to that of the seasonal influenza viruses that were circulating before and during the pandemic.
Localization (presentation) of pH1N1 associated with influenza virus infection
7) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012722 Disease Relevance 1.25 Pain Relevance 0.06
We recently reported on the epidemiologic and clinical presentation of pH1N1 and described a younger population than that affected by this virus in other parts of the world [22].
Localization (presentation) of pH1N1 in other parts
8) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012722 Disease Relevance 1.07 Pain Relevance 0

General Comments

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