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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.93
Pain Relevance 0.44

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cell differentiation (NRP1) cytosol (NRP1) signal transduction (NRP1)
extracellular region (NRP1) cell adhesion (NRP1) plasma membrane (NRP1)
Anatomy Link Frequency
cleavage 2
NRP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 3 93.68 High High
Abeta 9 87.04 High High
Disease Link Frequency Relevance Heat
Congenital Anomalies 1 96.00 Very High Very High Very High
INFLAMMATION 1 93.28 High High
Cognitive Disorder 1 92.16 High High
Alzheimer's Dementia 2 82.32 Quite High
Disease 4 78.64 Quite High
Targeted Disruption 2 77.84 Quite High
Brain Disease 1 63.68 Quite High
Toxicity 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These toxic effects are likely due to inhibition of Notch cleavage, a transmembrane receptor involved in regulating cell-fate decisions.
Negative_regulation (inhibition) of Protein_catabolism (cleavage) of transmembrane receptor in cleavage
1) Confidence 0.05 Published 2008 Journal Curr Top Med Chem Section Abstract Doc Link 18220933 Disease Relevance 0.93 Pain Relevance 0.44

General Comments

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