INT149294

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.90
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOTCH1) nucleoplasm (NOTCH1) extracellular region (NOTCH1)
Golgi apparatus (NOTCH1) plasma membrane (NOTCH1) nucleus (NOTCH1)
Anatomy Link Frequency
cleavage 2
NOTCH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 3 97.00 Very High Very High Very High
Abeta 9 86.88 High High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 2 99.36 Very High Very High Very High
INFLAMMATION 1 96.72 Very High Very High Very High
Brain Disease 1 86.40 High High
Congenital Anomalies 1 83.44 Quite High
Cognitive Disorder 1 79.60 Quite High
Disease 4 72.88 Quite High
Targeted Disruption 2 65.28 Quite High
Toxicity 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, some non-steroidal anti-inflammatory drugs (NSAIDs) and other small organic molecules have been found to modulate gamma-secretase and to selectively reduce beta-amyloid(1-42) (Abeta42) levels without affecting Notch cleavage.
Neg (without) Regulation (affecting) of Localization (cleavage) of Notch in cleavage associated with inflammation, alzheimer's dementia and cinod
1) Confidence 0.10 Published 2008 Journal Curr Top Med Chem Section Abstract Doc Link 18220933 Disease Relevance 0.90 Pain Relevance 0.55

General Comments

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