INT149297

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.87
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOTCH1) nucleoplasm (NOTCH1) extracellular region (NOTCH1)
Golgi apparatus (NOTCH1) plasma membrane (NOTCH1) nucleus (NOTCH1)
Anatomy Link Frequency
cleavage 2
Notch 1
NOTCH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 19 91.60 High High
Abeta 9 86.48 High High
aspirin 6 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 1 95.44 Very High Very High Very High
Cognitive Disorder 1 91.60 High High
INFLAMMATION 1 91.20 High High
Alzheimer's Dementia 10 80.24 Quite High
Disease 22 78.08 Quite High
Targeted Disruption 2 77.28 Quite High
Brain Disease 1 61.60 Quite High
Toxicity 10 25.00 Low Low
Neuroblastoma 4 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These toxic effects are likely due to inhibition of Notch cleavage, a transmembrane receptor involved in regulating cell-fate decisions.
Protein_catabolism (cleavage) of Notch in cleavage
1) Confidence 0.15 Published 2008 Journal Curr Top Med Chem Section Abstract Doc Link 18220933 Disease Relevance 0.87 Pain Relevance 0.44
42 and reducing Notch cleavage in our experiment.
Protein_catabolism (cleavage) of Notch in cleavage
2) Confidence 0.08 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0 Pain Relevance 0
For each of the 5 cell lines examined, cleavage of Notch by the ?
Protein_catabolism (cleavage) of Notch in Notch
3) Confidence 0.07 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0 Pain Relevance 0.07

General Comments

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