INT14930

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Context Info
Confidence 0.45
First Reported 1982
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 6.86
Pain Relevance 3.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SST) extracellular region (SST) cell-cell signaling (SST)
Anatomy Link Frequency
neurons 2
brain 2
SST (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 587 100.00 Very High Very High Very High
Catecholamine 6 99.30 Very High Very High Very High
Neurotransmitter 2 98.76 Very High Very High Very High
Morphine 3 94.96 High High
antagonist 11 90.88 High High
narcan 3 87.32 High High
agonist 73 85.16 High High
Dopamine 84 80.72 Quite High
dopamine receptor 8 77.04 Quite High
fibrosis 2 67.88 Quite High
Disease Link Frequency Relevance Heat
Cancer 549 100.00 Very High Very High Very High
Adenoma 26 99.72 Very High Very High Very High
Schistosomiasis 3 99.06 Very High Very High Very High
Diarrhoea 55 97.72 Very High Very High Very High
Insulin Resistance 2 97.16 Very High Very High Very High
Apoptosis 46 97.00 Very High Very High Very High
Adenocarcinoma 15 92.96 High High
Pancreatic Cancer 21 89.52 High High
Somatostatinoma 20 89.32 High High
Metastasis 70 86.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The regulation of receptor expression as well as receptor internalization can give us insight into the effect of exogenous somatostatin on schistosomiasis-mediated intestinal pathology, as well as its modulation by intrinsically produced somatostatin levels.
Regulation (modulation) of Gene_expression (produced) of somatostatin associated with somatostatin and schistosomiasis
1) Confidence 0.45 Published 2001 Journal Trop. Med. Int. Health Section Abstract Doc Link 11737838 Disease Relevance 0.70 Pain Relevance 0.40
This discrepancy between somatostatin analogue-induced tumour shrinkage and the ability of the compound to inhibit GH synthesis and secretion has been observed before in individual cases and appears to be due to the expression of a specific set of somatostatin receptor subtypes, particularly the sst3 subtype (as opposed to the usual expression in these tumours of subtypes 2 and 5).28,29
Regulation (discrepancy) of Gene_expression (analogue) of somatostatin associated with cancer and somatostatin
2) Confidence 0.44 Published 2007 Journal Clinical Endocrinology Section Body Doc Link PMC1974838 Disease Relevance 0.83 Pain Relevance 0.12
The anti tumour effects of SST analogues
Regulation (effects) of Gene_expression (analogues) of SST associated with cancer and somatostatin
3) Confidence 0.32 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 1.11 Pain Relevance 0.28
The effects of higher than usual dose of SST analogues
Regulation (effects) of Gene_expression (analogues) of SST associated with somatostatin
4) Confidence 0.32 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 0.61 Pain Relevance 0.19
The symptomatic and biochemical effects of SST analogues
Regulation (effects) of Gene_expression (analogues) of SST associated with somatostatin
5) Confidence 0.32 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 0.39 Pain Relevance 0.41
Several hypotheses can be put forward: a cumulative effect of SSTa concentration over time, an increase in hormonal efficacy of the treatment as reported after the reduction in adenoma volume by surgical debulking,26,27 although there was no significant correlation between hormonal control and the change in adenoma volume, or a change in the expression of the SST receptor subtypes on the adenoma cells.
Regulation (change) of Gene_expression (expression) of SST associated with adenoma
6) Confidence 0.26 Published 2007 Journal Clinical Endocrinology Section Body Doc Link PMC1974833 Disease Relevance 0.38 Pain Relevance 0.20
The synthesis and secretion of the natural ligand somatostatin-14 by sst2-transfected cells was responsible for an autocrine/paracrine inhibitory loop [57].
Regulation (responsible) of Gene_expression (synthesis) of somatostatin associated with somatostatin
7) Confidence 0.22 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 0.94 Pain Relevance 0.16
Biological response to somatostatin analogs depends on distribution and level of expression of SSTRs subtypes in tumours, and the expression of selective somatostatin receptor-signaling pathway molecules.
Regulation (depends) of Gene_expression (expression) of somatostatin associated with cancer and somatostatin
8) Confidence 0.22 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 0.82 Pain Relevance 0.36
Furthermore, because the efficacy of pegvisomant is not dependent on tumor somatostatin receptor expression, pegvisomant effectively inhibits IGF-1 secretion in patients who are non- or partial responders to somatostatin analogues.
Neg (not) Regulation (dependent) of Gene_expression (expression) of somatostatin associated with cancer and somatostatin
9) Confidence 0.10 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2887860 Disease Relevance 0.92 Pain Relevance 0.61
Levels of vasoactive intestinal polypeptide, somatostatin, and pancreatic glucagon were not affected.
Neg (not) Regulation (affected) of Gene_expression (Levels) of somatostatin associated with somatostatin
10) Confidence 0.02 Published 1982 Journal Am. J. Gastroenterol. Section Abstract Doc Link 7051818 Disease Relevance 0 Pain Relevance 0.45
A cohort of brain neurotransmitters, especially catecholamines and acetylcholine, play a crucial role in the control of neurosecretory growth hormone-releasing hormone (GH-RH)- and somatostatin (SS)-producing neurons, and hence growth hormone (GH) secretion.
Regulation (role) of in neurons Gene_expression (producing) of somatostatin in brain associated with neurotransmitter, catecholamine and somatostatin
11) Confidence 0.01 Published 1991 Journal Drugs Section Abstract Doc Link 1709847 Disease Relevance 0.07 Pain Relevance 0.35
A cohort of brain neurotransmitters, especially catecholamines and acetylcholine, play a crucial role in the control of neurosecretory growth hormone-releasing hormone (GH-RH)- and somatostatin (SS)-producing neurons, and hence growth hormone (GH) secretion.
Regulation (control) of in neurons Gene_expression (producing) of somatostatin in brain associated with neurotransmitter, catecholamine and somatostatin
12) Confidence 0.01 Published 1991 Journal Drugs Section Abstract Doc Link 1709847 Disease Relevance 0.07 Pain Relevance 0.35

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