INT149332

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 13.63
Pain Relevance 3.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD163) plasma membrane (CD163)
Anatomy Link Frequency
macrophages 6
immune cells 1
liver sinusoids 1
Skin 1
adipose tissue 1
CD163 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 167 99.24 Very High Very High Very High
pulpitis 10 98.72 Very High Very High Very High
rheumatoid arthritis 375 98.44 Very High Very High Very High
Arthritis 442 95.96 Very High Very High Very High
Osteoarthritis 50 91.44 High High
palliative 1 90.28 High High
imagery 3 87.64 High High
Calcitonin gene-related peptide 4 83.36 Quite High
corticosteroid 28 81.88 Quite High
Pain 10 80.52 Quite High
Disease Link Frequency Relevance Heat
Histiocytic Sarcoma 71 99.70 Very High Very High Very High
Hyperplasia 24 99.58 Very High Very High Very High
INFLAMMATION 151 99.24 Very High Very High Very High
Pigmented Villonodular Synovitis 24 99.04 Very High Very High Very High
Cancer 126 98.78 Very High Very High Very High
Pulpitis 10 98.72 Very High Very High Very High
Rheumatoid Arthritis 375 98.44 Very High Very High Very High
Obesity 81 97.76 Very High Very High Very High
Carcinoma 37 97.36 Very High Very High Very High
Overweight 79 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Autopsy revealed the proliferation of tumor cells within the splenic sinus and the liver sinusoids, which displayed extreme hemophagocytosis and strong expression of the histiocytic markers CD68 (KP1 and PG-M1) and CD163.
Gene_expression (expression) of CD163 in liver sinusoids associated with cancer
1) Confidence 0.75 Published 2008 Journal Int. J. Hematol. Section Abstract Doc Link 18224419 Disease Relevance 0.91 Pain Relevance 0.21
Results demonstrated that a high percentage of total viable AAMø CD163+ expressed CGRPr on their membranes (72.12% in healthy pulp, 62.20% in irreversible pulpitis, and 58.01% in induced pulpitis).
Gene_expression (expressed) of CD163 associated with pulpitis
2) Confidence 0.66 Published 2008 Journal J Endod Section Abstract Doc Link 18634925 Disease Relevance 0.60 Pain Relevance 0.63
It can be concluded that AAMø CD163+ are expressed during normal and inflammatory processes, supporting the hypothesis that they could exercise an anti-inflammatory action that could be controlled by CGRP signaling after its binding.
Gene_expression (expressed) of CD163 associated with inflammation
3) Confidence 0.66 Published 2008 Journal J Endod Section Abstract Doc Link 18634925 Disease Relevance 0.71 Pain Relevance 0.65
The key feature suggestive of HS is the strong expression of one or more "histiocytic markers", including CD163, CD68, and lysozyme in the majority of neoplastic cells.
Gene_expression (expression) of CD163 associated with histiocytic sarcoma
4) Confidence 0.51 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1808440 Disease Relevance 1.26 Pain Relevance 0
in a bivariate logistic regression model including either the numbers of CD68+ sublining macrophages, CD163+, MPR8+, MRP14+ macrophages, or CD3+ T cells, these cellular markers were no longer significantly associated with response.
Gene_expression (macrophages) of CD163 in macrophages
5) Confidence 0.47 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564801 Disease Relevance 0.08 Pain Relevance 0
They were strongly positive for CD163 (Fig. 4), CD68, lysozyme, NSE, and vimentin.
Gene_expression (positive) of CD163
6) Confidence 0.44 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1808440 Disease Relevance 0.33 Pain Relevance 0
Using histological parameters that discriminate between SpA and RA, such as lining layer thickness, degree of vascularity, presence of PMCs and CD163 expression, we were unable to demonstrate any significant differences between oligoarticular and polyarticular PsA.
Gene_expression (expression) of CD163 associated with rheumatoid arthritis and arthritis
7) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174942 Disease Relevance 1.41 Pain Relevance 0.65
Frozen sections of the synovial biopsies were stained with the following antibodies (from Dako [Glostrup, Denmark], unless otherwise stated): anti-CD3 (T cells, clone UCHT1), anti-CD4 (T-helper cells, clone MT310), anti-CD8 (cytotoxic T cells, clone DK25), anti-CD20 (B cells, clone L26), anti-CD38 (plasma cells, clone AT13/5), anti-CD138 (plasma cells, clone CBL455; Chemicon, Temecula, CA, USA), anti-CD68 (pan-macrophage marker expressed on monocytes and macrophages, clone EBM11), anti-CD163 (scavenger receptor expressed on resident tissue macrophages, clone Ber-MAC3), anti-CD83 (dendritic cells, clone HB15A; Immunotech SA, Marseille, France), anti-CD1a (interdigitating dendritic cells, clone NA1/34), anti-CD146 (endothelial cells, clone P1H12; Chemicon), anti-?
Gene_expression (expressed) of CD163 in T cells
8) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174942 Disease Relevance 0.19 Pain Relevance 0
CD163 is a member of the scavenger receptor cystein-rich family class B and is expressed on most subpopulations of mature tissue macrophages [30].
Gene_expression (expressed) of CD163 in macrophages
9) Confidence 0.39 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0 Pain Relevance 0
In the case of CD163 and CD20 expression, we would have expected differences between RA and SpA patients considering previous immunohistochemical observations [31,32], which was not confirmed.
Gene_expression (expression) of CD163 associated with rheumatoid arthritis
10) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875643 Disease Relevance 0.60 Pain Relevance 0.18
Expression of CD14 and CD163 was decreased by enzyme exposure but not further decreased by rotation (Figure 3b).
Gene_expression (Expression) of CD163
11) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875643 Disease Relevance 0.17 Pain Relevance 0
In addition, we were able to detect TLR4 protein on endometrial CD14 and CD163 positive immune cells.
Gene_expression (detect) of CD163 in immune cells
12) Confidence 0.34 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.27 Pain Relevance 0.08
Within these groups of genes, gene expression of specific macrophage markers [e.g., CD14, CD163 and macrophage scavenger receptor 1 (MSR1)] was significantly higher in adipose tissue of overweight subjects (P < 0.001 for BMI-effect in two-way ANOVA), pointing towards presence of macrophages or inflammatory cells in the adipose tissue biopsies from overweight subjects.
Gene_expression (expression) of CD163 in adipose tissue associated with inflammation, obesity and overweight
13) Confidence 0.31 Published 2008 Journal Genes Nutr Section Body Doc Link PMC2593008 Disease Relevance 1.51 Pain Relevance 0.05
TLR4 protein was expressed on CD14 positive dendritic cells, and monocytes (figure 7A, C), as well as on CD163 positive macrophages (figure 7B, D).


Gene_expression (expressed) of CD163 in macrophages
14) Confidence 0.29 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.79 Pain Relevance 0.03
g/ml, mouse anti-human, BioLegend, San Diego, CA) or CD163 (10 ?
Gene_expression (human) of CD163
15) Confidence 0.29 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0 Pain Relevance 0
Harvested grafts maintained characteristic features of the original tumors with respect to tumor morphology, CSF1 translocation status, CSF1, and macrophage CD163 expression, making this the first PVNS model of practical use for preclinical therapeutic investigation.
Gene_expression (expression) of CD163 in macrophage associated with pigmented villonodular synovitis and cancer
16) Confidence 0.25 Published 2010 Journal Sarcoma Section Body Doc Link PMC2957133 Disease Relevance 1.38 Pain Relevance 0
In order to delineate severity of local tissue inflammation, we investigated lining layer thickness, overall cellularity, density of CD3+ T cells, CD163+ macrophages, and vascularity.
Gene_expression (macrophages) of CD163 in macrophages associated with inflammation
17) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257423 Disease Relevance 0.61 Pain Relevance 0.30
We compared the PsA subgroups with respect to those synovial features that appeared to discriminate best between SpA and RA in the previous experiments or that have been reported in the literature [8]: lining layer hyperplasia, vascularity, PMCs, CD163+ and CD68+ macrophages, and expression of E-selectin.
Gene_expression (expression) of CD163 in macrophages associated with rheumatoid arthritis, hyperplasia and arthritis
18) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174942 Disease Relevance 1.56 Pain Relevance 0.70
Skin biopsy of these lesions shows a characteristic vacuolated histiocytic infiltrate which contains Touton giant cells in 85% of the cases and a characteristic positivity of the lesions to factor XIIIa, CD68, CD163, fascin, and CD14 but negative S100 and CD1 on immunohistochemistry [10].
Neg (negative) Gene_expression (negative) of CD163 in Skin
19) Confidence 0.15 Published 2009 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2770547 Disease Relevance 1.26 Pain Relevance 0.17

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