INT149335

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Context Info
Confidence 0.57
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 2.93
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pik3cb) signal transduction (Pik3cb) cell adhesion (Pik3cb)
nucleus (Pik3cb) cytoplasm (Pik3cb)
Anatomy Link Frequency
DLN 1
striatum 1
oocytes 1
Pik3cb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 4 100.00 Very High Very High Very High
Glutamate 8 99.92 Very High Very High Very High
excitatory amino acid 2 99.60 Very High Very High Very High
Arthritis 78 99.42 Very High Very High Very High
Neurotransmitter 3 98.56 Very High Very High Very High
Central nervous system 3 97.60 Very High Very High Very High
Dopamine 103 97.40 Very High Very High Very High
central pain 1 93.20 High High
Inflammation 80 92.24 High High
withdrawal 2 89.36 High High
Disease Link Frequency Relevance Heat
Arthritis 81 99.42 Very High Very High Very High
Cancer 32 97.92 Very High Very High Very High
Necrosis 9 97.44 Very High Very High Very High
Apoptosis 59 93.28 High High
Pain 2 92.88 High High
INFLAMMATION 92 92.24 High High
Death 10 88.16 High High
Diabetes Mellitus 6 84.08 Quite High
Infection 20 83.96 Quite High
Aging 38 83.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The link between the PI3K pathway and the actions of AMPH is further fortified by recent studies from our laboratory as well as others, showing that prolonged exposure to AMPH ex vivo and in vivo inhibits PI3K signaling, as measured by Akt activity in striatum [29,63].
Gene_expression (pathway) of PI3K in striatum
1) Confidence 0.57 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.29 Pain Relevance 0.24
Paradoxically, these increases in Akt phosphorylation were associated with diminished mammalian target of rapamycin (mTOR) phosphorylation, along with decreased levels of insulin receptor beta (IR-?)
Gene_expression (levels) of PI3K
2) Confidence 0.34 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2712760 Disease Relevance 0.30 Pain Relevance 0.21
PI3K gene was successfully knocked down in MSCs by transfection with PI3K siRNA as compared to scrambled siRNA (Sc siRNA) transfected cells which was indicated by abrogation of pAkt expression (Figure S2).
Gene_expression (transfection) of PI3K
3) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0 Pain Relevance 0
Treatment of the cells with Shh or instrinsic Shh gene overexpression in response to various factors involve signaling pathways including PI3K/Akt, Ras/ERK and PKC.
Gene_expression (pathways) of PI3K
4) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.07 Pain Relevance 0
The expression levels of PI3K, PKB/Akt, IKK?
Gene_expression (expression) of PI3K
5) Confidence 0.31 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526584 Disease Relevance 0.52 Pain Relevance 0.10
In addition to BzATP, NMDA and BDNF were able to elicit survival in conditions of sustained PI3K inactivation with the inhibitor LY-294002 (50 ?
Gene_expression (inactivation) of PI3K
6) Confidence 0.28 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.18 Pain Relevance 0.07
Analysis of synovia and DLN protein extracts revealed a decreased expression level of PI3K, PKB/Akt, IKK, NF-?
Gene_expression (expression) of PI3K in DLN
7) Confidence 0.27 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1526584 Disease Relevance 1.01 Pain Relevance 0.48
Induction of AIA induced upregulation in the expression level of various key signaling proteins such as PI3K, PKB/Akt (total and phosphorylated) and TNF-?
Gene_expression (expression) of PI3K associated with arthritis
8) Confidence 0.24 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526584 Disease Relevance 0.27 Pain Relevance 0.17
Engagement of integrin receptors during this process initiates several signal transduction pathways such as extracellular-signal-regulated kinase (ERK), phophatidylinositol 3-kinase (PI3K) and protein kinases A and C (PKA and PKC) which may contribute to the observed changes in CYP after administration of any of the vectors included in this study [34-36].
Spec (observed) Gene_expression (changes) of PI3K
9) Confidence 0.21 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.12 Pain Relevance 0
Expression of genes associated with the PI3K, PKC and nuclear factor kappa B (NFKB) pathways were induced with respect to those found in saline treated animals on average by a factor of 3.8, 4 and 4.6 respectively by each of the viruses included in this study.
Gene_expression (Expression) of PI3K
10) Confidence 0.18 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.08 Pain Relevance 0.03
Ethanol increases the activity of rat excitatory amino acid transporter type 4 expressed in Xenopus oocytes: role of protein kinase C and phosphatidylinositol 3-kinase.
Gene_expression (expressed) of phosphatidylinositol 3-kinase in oocytes associated with kinase c and excitatory amino acid
11) Confidence 0.06 Published 2008 Journal Alcohol. Clin. Exp. Res. Section Title Doc Link 18226120 Disease Relevance 0.09 Pain Relevance 0.51

General Comments

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