INT149339

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.17
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcna1) transmembrane transport (Kcna1)
Kcna1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuronal excitability 2 81.40 Quite High
Hippocampus 2 71.40 Quite High
hyperexcitability 1 64.08 Quite High
Neuropathic pain 1 60.00 Quite High
Spinal cord 1 56.08 Quite High
depression 1 15.76 Low Low
Somatostatin 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
potassium channel 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 1 96.60 Very High Very High Very High
Ataxia 21 76.56 Quite High
Depression 1 15.76 Low Low
Camurati-engelmann Disease 2 5.00 Very Low Very Low Very Low
Epilepsy 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Neuropathic Pain 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low
Shock 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compounds were found to act by several mechanisms to prevent Kvbeta1 inactivation of Kv1.1 channels, including enhancement of Ca(2+) release/influx and by direct mechanisms.
Positive_regulation (inactivation) of Positive_regulation (enhancement) of Kv1
1) Confidence 0.32 Published 2008 Journal Bioorg. Med. Chem. Section Abstract Doc Link 18226531 Disease Relevance 0.10 Pain Relevance 0.24
Maximal activation of BK channels (alias maxiK, KCNMA1, KCa1.1 or slowpoke) requires both membrane depolarization and increased intracellular Ca2+[4], [5].
Positive_regulation (increased) of Positive_regulation (activation) of KCa1
2) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776494 Disease Relevance 0.08 Pain Relevance 0

General Comments

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