INT149384

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.41
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (TRPV4) plasma membrane (TRPV4) transmembrane transport (TRPV4)
Anatomy Link Frequency
keratinocytes 1
TRPV4 (Homo sapiens)
Pain Link Frequency Relevance Heat
vincristine 2 99.46 Very High Very High Very High
Hyperalgesia 9 98.76 Very High Very High Very High
intrathecal 1 93.72 High High
agonist 3 90.00 High High
TRP channel 4 89.40 High High
member 8 1 89.36 High High
peripheral neuropathy 1 85.36 High High
Pain 19 84.48 Quite High
Calcium channel 1 79.76 Quite High
Mechanotransduction 1 67.12 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 1 99.96 Very High Very High Very High
Diabetes Mellitus 27 99.72 Very High Very High Very High
Disease 1 99.24 Very High Very High Very High
Hyperalgesia 10 98.76 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 90.68 High High
Alcohol Addiction 1 87.48 High High
Peripheral Neuropathy 3 85.36 High High
Mouth Disease 1 84.20 Quite High
Charcot Marie Tooth Disease 2 83.64 Quite High
Neuropathic Pain 16 81.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further analysis reduced the CMT2C risk locus to a 4-Mb region.
Negative_regulation (reduced) of CMT2C
1) Confidence 0.43 Published 2010 Journal Nat. Genet. Section Abstract Doc Link 20037587 Disease Relevance 0.59 Pain Relevance 0.13
Similarly, mechanical hyperalgesia induced by paclitaxel, vincristine, or diabetes was strongly reduced in TRPV4 knock-out mice.
Negative_regulation (reduced) of TRPV4 associated with targeted disruption, vincristine, hyperalgesia and diabetes mellitus
2) Confidence 0.37 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18234883 Disease Relevance 1.29 Pain Relevance 0.98
The Ca2+ concentration at which CaM binding to P5 was half-maximal is higher than the IC50 for steady-state inhibition of TRPV4 by intracellular Ca2+ in electrophysiological experiments (around 600 nM, [25]).
Negative_regulation (inhibition) of TRPV4
3) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0.09
Positive but patchy immunostaining of TRPV4 basal keratinocytes was observed (Fig 8E).
Negative_regulation (immunostaining) of TRPV4 in keratinocytes
4) Confidence 0.34 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.54 Pain Relevance 0.03

General Comments

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