INT149385

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 14
Disease Relevance 7.22
Pain Relevance 6.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (TRPV4) plasma membrane (TRPV4) transmembrane transport (TRPV4)
Anatomy Link Frequency
nerve 1
spikes 1
keratinocytes 1
nociceptors 1
kidney 1
TRPV4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hyperalgesia 13 99.40 Very High Very High Very High
dorsal root ganglion 96 99.20 Very High Very High Very High
Pain 262 98.88 Very High Very High Very High
Nerve growth factor 93 97.32 Very High Very High Very High
TRP channel 23 96.96 Very High Very High Very High
agonist 12 96.32 Very High Very High Very High
nociceptor 31 95.20 Very High Very High Very High
qutenza 43 92.80 High High
Spinal cord 33 92.60 High High
Inflammation 24 92.40 High High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 6 100.00 Very High Very High Very High
Hyperalgesia 25 99.40 Very High Very High Very High
Ganglion Cysts 99 99.20 Very High Very High Very High
Pain 243 98.88 Very High Very High Very High
INFLAMMATION 22 92.40 High High
Injury 61 92.08 High High
Targeted Disruption 3 91.20 High High
Macromastia 15 90.48 High High
Diabetes Mellitus 77 89.76 High High
Neuropathic Pain 45 88.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also show that alpha2beta1 integrin and Src tyrosine kinase, which have been implicated in mechanical transduction, are important for the development of mechanical hyperalgesia, and that their contribution requires TRPV4.
Positive_regulation (requires) of TRPV4 associated with hyperalgesia
1) Confidence 0.69 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18234883 Disease Relevance 1.17 Pain Relevance 0.92
In nominally Ca2+-free solutions, activation of TRPV4 by the phorbol ester 4?
Positive_regulation (activation) of TRPV4
2) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0.09
Initial temperature induced rapid transient spikes and subsequent slower rise reflect TRPV1 and TRPV4 channel activation, respectively.
Positive_regulation (activation) of TRPV4 in spikes
3) Confidence 0.45 Published 2009 Journal Molecular pain Section Body Doc Link 19695100 Disease Relevance 0.13 Pain Relevance 0
RESULTS: Fluorescent imaging of Fura-2 loaded human SW982 synoviocytes reveals immediate and delayed cytosolic calcium oscillations elicited by (1) TRPV1 agonists capsaicin and resiniferatoxin (20-40% of cells), (2) moderate and noxious temperature change, and (3) osmotic stress TRPV4 activation (11.5% of cells).
Positive_regulation (activation) of TRPV4
4) Confidence 0.45 Published 2009 Journal Molecular pain Section Body Doc Link 19695100 Disease Relevance 0.17 Pain Relevance 0
It may be speculated that increased TRPV3 and TRPV4 in observed in keratinocytes may alter keratinocyte expression of NGF and other molecules, which in turn may sensitise nociceptors.


Positive_regulation (increased) of TRPV4 in nociceptors associated with nerve growth factor and nociceptor
5) Confidence 0.40 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC554997 Disease Relevance 0.62 Pain Relevance 0.97
The recently discovered vanilloid thermoreceptors TRPV3 and TRPV4, which are also expressed by sensory fibres and activated by warmth, were also studied [17,18].


Positive_regulation (activated) of TRPV4 associated with increased venous pressure under development
6) Confidence 0.40 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC554997 Disease Relevance 1.07 Pain Relevance 0.95
Both TRPV3 and TRPV4 were significantly increased in keratinocytes in breast pain tissues; TRPV3, median [range] – no pain group, n = 6, 0.75 [0–2]; pain group, n = 11, 2 [1-3], p = 0.008; TRPV4, median [range] – no pain group, n = 6, [0–1]; pain group, n = 11, 1 [0.5–2], p = 0.014).


Positive_regulation (increased) of TRPV4 in keratinocytes associated with pain
7) Confidence 0.40 Published 2005 Journal BMC Womens Health Section Abstract Doc Link PMC554997 Disease Relevance 0.99 Pain Relevance 1.43
We provide experimental evidence for an underlying mechanism in which an N-terminal autoinhibitory domain forms a molecular switch that controls facilitation of TRPV4.


Positive_regulation (facilitation) of TRPV4
8) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0.06
TRPV4 is highly expressed in kidney and was originally found to be activated by hypotonic solutions, suggesting a role in renal osmoregulation [12], [13], [14].
Positive_regulation (activated) of TRPV4 in kidney
9) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0.16
Interestingly, both stimulation of CFP-TRPV4-YFP by decreases in the extracellular osmolarity (Fig. 5C) or application of 4?
Positive_regulation (stimulation) of TRPV4-YFP
10) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0
Related receptors TRPV4, activated by warmth and eicosanoids, and TRPM8, activated by cool and menthol, have been characterised in pre-clinical models.
Positive_regulation (activated) of TRPV4 associated with increased venous pressure under development
11) Confidence 0.37 Published 2007 Journal BMC Neurol Section Abstract Doc Link PMC1892784 Disease Relevance 0.84 Pain Relevance 0.37
TRPV1 and TRPV3 were significantly increased in injured brachial plexus nerves, and TRPV1 in hypersensitive skin after nerve repair, whilst TRPV4 was unchanged.
Neg (unchanged) Positive_regulation (unchanged) of TRPV4 in nerve
12) Confidence 0.37 Published 2007 Journal BMC Neurol Section Abstract Doc Link PMC1892784 Disease Relevance 1.34 Pain Relevance 0.53
Related receptors TRPV4, activated by warmth and eicosanoids, and TRPM8, activated by cool and menthol, have been characterised in pre-clinical models.
Positive_regulation (activated) of TRPV4 associated with increased venous pressure under development
13) Confidence 0.37 Published 2007 Journal BMC Neurol Section Abstract Doc Link PMC1892784 Disease Relevance 0.82 Pain Relevance 0.36
The TRPV4 C-terminal CaM binding site which is required for positive regulation [43] shows some conservation with OSM-9 (HAB, unpublished).
Positive_regulation (required) of TRPV4
14) Confidence 0.13 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2729924 Disease Relevance 0 Pain Relevance 0.18

General Comments

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