INT149387

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Context Info
Confidence 0.59
First Reported 2007
Last Reported 2010
Negated 2
Speculated 4
Reported most in Body
Documents 55
Total Number 59
Disease Relevance 21.91
Pain Relevance 28.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpa1) transmembrane transport (Trpa1)
Anatomy Link Frequency
neurons 7
nociceptors 6
nerve 2
skin 2
neuronal 1
Trpa1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 427 100.00 Very High Very High Very High
nociceptor 609 99.96 Very High Very High Very High
Mechanotransduction 182 99.84 Very High Very High Very High
Pain 574 99.80 Very High Very High Very High
c fibre 419 99.60 Very High Very High Very High
qutenza 830 99.32 Very High Very High Very High
Analgesic 44 99.20 Very High Very High Very High
Hyperalgesia 161 98.88 Very High Very High Very High
Mechanosensation 123 98.72 Very High Very High Very High
allodynia 237 98.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 242 99.84 Very High Very High Very High
Pain 607 99.80 Very High Very High Very High
Sprains And Strains 428 99.68 Very High Very High Very High
Stress 35 99.28 Very High Very High Very High
Nervous System Injury 205 99.12 Very High Very High Very High
Targeted Disruption 104 99.04 Very High Very High Very High
Hyperalgesia 192 98.88 Very High Very High Very High
Hypersensitivity 259 98.84 Very High Very High Very High
Cold Sores 136 98.58 Very High Very High Very High
Neuropathic Pain 578 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, two recent studies demonstrate that pharmacological inhibition of TRPA1 inhibits behavioral mechanical hyperalgesia after peripheral inflammation or neuropathic pain [25,28].
Negative_regulation (inhibition) of TRPA1 associated with hyperalgesia, inflammation and neuropathic pain
1) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2681449 Disease Relevance 0.52 Pain Relevance 0.64
We show here that acute pharmacological inhibition of TRPA1 substantially decreases the responsiveness of nociceptors to both formalin and mechanical force.
Negative_regulation (inhibition) of TRPA1 in nociceptors associated with nociceptor
2) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2681449 Disease Relevance 0.53 Pain Relevance 0.79
These data parallel the acute inhibition of TRPA1 by showing that either genetic ablation or pharmacological inhibition of TRPA1 inhibits C fiber responsiveness to formalin.
Negative_regulation (inhibition) of TRPA1 associated with c fibre
3) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2681449 Disease Relevance 0 Pain Relevance 0.84
Pharmacologic blockade of TRPA1 decreases mechanically-evoked firing in rat C fiber nociceptors
Negative_regulation (blockade) of TRPA1 in nociceptors associated with c fibre and nociceptor
4) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2681449 Disease Relevance 0.18 Pain Relevance 0.97
Nociceptors were not affected by HC-030031 in mice that lack functional TRPA1, indicating that the effects of HC-030031 are mediated by on-target inhibition of TRPA1.
Negative_regulation (inhibition) of TRPA1 in Nociceptors associated with nociceptor
5) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2681449 Disease Relevance 0 Pain Relevance 0.36
We also examined the effects of acute inhibition of TRPA1 on mechanotransduction in the peripheral terminal.
Spec (examined) Negative_regulation (inhibition) of TRPA1 associated with mechanotransduction
6) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2681449 Disease Relevance 0 Pain Relevance 0.40
These data parallel the acute inhibition of TRPA1 by showing that either genetic ablation or pharmacological inhibition of TRPA1 inhibits C fiber responsiveness to formalin.
Negative_regulation (inhibition) of TRPA1 associated with c fibre
7) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2681449 Disease Relevance 0 Pain Relevance 0.82
To further determine whether the capacity of HC-030031 to inhibit mechanical firing in rat C fiber nociceptors was due specifically to inhibition of TRPA1 or to other off-target mechanisms, we investigated the effect of HC-030031 on mechanical firing in C fibers from TRPA1 deficient (Trpa1-/-) mice [18].
Negative_regulation (inhibition) of TRPA1 in nociceptors associated with c fibre and nociceptor
8) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2681449 Disease Relevance 0 Pain Relevance 0.66
Inhibiting TRPA1 activity decreased the responsiveness of C fibers to high intensity mechanical force in both rat and mouse.
Negative_regulation (Inhibiting) of TRPA1
9) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2681449 Disease Relevance 0 Pain Relevance 0.39
These data indicate that developmental disruption of TRPA1 does not affect capsaicin responsiveness.


Negative_regulation (disruption) of TRPA1 associated with qutenza
10) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2681449 Disease Relevance 0.17 Pain Relevance 0.99
Thus, TRPA1 plays a significant role in the peripheral detection of noxious stimuli and pharmacological inhibition of TRPA1 may have significant utility as a treatment for acute or chronic pain that includes mechanical hypersensitivity.


Negative_regulation (inhibition) of TRPA1 associated with lasting pain and hypersensitivity
11) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2681449 Disease Relevance 0.19 Pain Relevance 0.37
Although it is possible that this discrepancy is due to developmental effects either at the molecular or cellular level, it is also possible that this difference results from a local versus a global reduction in TRPA1 function.
Negative_regulation (reduction) of TRPA1
12) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2681449 Disease Relevance 0.39 Pain Relevance 0.67
In parallel, acute pharmacological inhibition of TRPA1 recapitulated the genetic ablation data by showing that C fibers have markedly decreased firing rates to mechanical stimuli when a TRPA1 antagonist [15] is concomitantly applied to their receptive field [16].
Negative_regulation (inhibition) of TRPA1 associated with antagonist
13) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922334 Disease Relevance 0.09 Pain Relevance 0.35
Pharmacological blockade of TRPA1 inhibits mechanical firing in nociceptors

Background

Negative_regulation (blockade) of TRPA1 in nociceptors associated with nociceptor
14) Confidence 0.43 Published 2009 Journal Mol Pain Section Title Doc Link PMC2681449 Disease Relevance 0.18 Pain Relevance 0.51
Acute application of HC-030031, a selective TRPA1 antagonist, inhibited all formalin responses in rat C fibers but had no effect on TRPV1 function, assessed by capsaicin responsiveness.
Negative_regulation (antagonist) of TRPA1 associated with qutenza and antagonist
15) Confidence 0.43 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2681449 Disease Relevance 0.17 Pain Relevance 0.55
Using a pharmacological approach, we examined the effects of acute, local inhibition of TRPA1 on transduction in cutaneous afferent terminals.
Spec (examined) Negative_regulation (inhibition) of TRPA1
16) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2681449 Disease Relevance 0 Pain Relevance 0.29
Recent work demonstrates that inhibiting TRPA1 function reduces mechanical hypersensitivity produced by inflammation.
Negative_regulation (inhibiting) of TRPA1 associated with inflammation and hypersensitivity
17) Confidence 0.43 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2681449 Disease Relevance 0.20 Pain Relevance 0.28
Taken together, we conclude that TRPA1 plays a significant role in the normal detection of noxious stimuli and that pharmacological inhibition of TRPA1 could have significant utility as a treatment for mechanical pain.


Negative_regulation (inhibition) of TRPA1 associated with pain
18) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2681449 Disease Relevance 0.49 Pain Relevance 0.74
The specificity of the HC-030031-mediated inhibition of the formalin evoked responses underscores the likelihood that this antagonist exerts its effects by blocking TRPA1 rather than by affecting other aspects of neuronal firing.
Negative_regulation (blocking) of TRPA1 in neuronal associated with antagonist
19) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2681449 Disease Relevance 0 Pain Relevance 0.35
Despite the wealth of data examining the effects of genetic ablation of TRPA1, few studies have probed the effects of acutely inhibiting TRPA1.
Negative_regulation (inhibiting) of TRPA1
20) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2681449 Disease Relevance 0.31 Pain Relevance 0.59

General Comments

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