INT149394

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Context Info
Confidence 0.12
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.89
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mul1) mitochondrion (Mul1) peroxisome (Mul1)
nucleus (Mul1) ligase activity (Mul1) cytoplasm (Mul1)
Mul1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 32 98.52 Very High Very High Very High
Inflammation 43 98.12 Very High Very High Very High
rheumatoid arthritis 12 90.24 High High
Pain 2 80.76 Quite High
TRP channel 7 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 5 98.86 Very High Very High Very High
Cancer 13 98.68 Very High Very High Very High
INFLAMMATION 46 98.12 Very High Very High Very High
Arthropathy 1 96.00 Very High Very High Very High
Aging 1 91.28 High High
Frailty 19 90.80 High High
Rheumatoid Arthritis 12 90.24 High High
Uremia 5 85.24 High High
Chronic Renal Failure 28 80.00 Quite High
Disease 42 79.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The UPS degrades a specific protein depending on which E3 ubiquitin ligase is activated.
Positive_regulation (activated) of E3 ubiquitin ligase
1) Confidence 0.12 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 1.00 Pain Relevance 0.07
These activated kinases recruit tumor necrosis factor receptor-associated factor (TRAF) 6, which is an E3 ubiquitin ligase required for activation of NF?
Positive_regulation (required) of E3 ubiquitin ligase associated with necrosis and cancer
2) Confidence 0.10 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.36 Pain Relevance 0.08
Triad3A acts as an E3 ubiquitin ligase promoting the degradation of TLR 4 and 9.
Positive_regulation (promoting) of E3 ubiquitin ligase
3) Confidence 0.10 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.18 Pain Relevance 0.18
-arrestin 1 serves as an adaptor for an E3 ubiquitin ligase required for TRPV4 ubiquitination.
Positive_regulation (required) of E3 ubiquitin ligase
4) Confidence 0.09 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
Synoviolin is an E3 ubiquitin ligase that is involved in ERAD.
Positive_regulation (involved) of E3 ubiquitin ligase
5) Confidence 0.05 Published 2008 Journal Nature clinical practice. Rheumatology Section Abstract Doc Link 18235538 Disease Relevance 0.35 Pain Relevance 0.20

General Comments

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