INT149424

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 0.17
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GRIA1) endoplasmic reticulum (GRIA1) plasma membrane (GRIA1)
Anatomy Link Frequency
skin 2
GRIA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 184 54.88 Quite High
Glutamate receptor 30 50.00 Quite Low
Inflammation 1 50.00 Quite Low
Glutamate 52 5.00 Very Low Very Low Very Low
depression 24 5.00 Very Low Very Low Very Low
Central nervous system 12 5.00 Very Low Very Low Very Low
Neurotransmitter 12 5.00 Very Low Very Low Very Low
headache 8 5.00 Very Low Very Low Very Low
trigeminal ganglion 4 5.00 Very Low Very Low Very Low
central sensitization 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Pain 2 64.68 Quite High
Headache 180 54.88 Quite High
INFLAMMATION 1 50.00 Quite Low
Depression 24 5.00 Very Low Very Low Very Low
Epilepsy 20 5.00 Very Low Very Low Very Low
Disease 20 5.00 Very Low Very Low Very Low
Migraine With Aura 12 5.00 Very Low Very Low Very Low
Shock 8 5.00 Very Low Very Low Very Low
Neuroblastoma 4 5.00 Very Low Very Low Very Low
Ganglion Cysts 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Primers used for GRIA1 SNP rs2195450 were:
Positive_regulation (for) of Gene_expression (rs2195450) of GRIA1
1) Confidence 0.49 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.05 Pain Relevance 0.05
Primers used for GRIA1 SNP rs548294 were:
Positive_regulation (for) of Gene_expression (rs548294) of GRIA1
2) Confidence 0.49 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0 Pain Relevance 0
Primers used for GRIA1 SNP rs2195450 were:
Positive_regulation (used) of Gene_expression (rs2195450) of GRIA1
3) Confidence 0.49 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.05 Pain Relevance 0.05
Primers used for GRIA1 SNP rs548294 were:
Positive_regulation (for) of Gene_expression (used) of GRIA1
4) Confidence 0.49 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: These results, in human tissue, demonstrate that iGluR mRNA and protein expression are increased during persistent inflammation and that this increased activity may be involved in mediating clinical inflammatory pain in human skin.


Positive_regulation (increased) of Gene_expression (expression) of iGluR in skin
5) Confidence 0.01 Published 2008 Journal Br J Anaesth Section Body Doc Link 18238837 Disease Relevance 0.06 Pain Relevance 0

General Comments

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