INT149425

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Context Info
Confidence 0.52
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.66
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GRIA1) endoplasmic reticulum (GRIA1) plasma membrane (GRIA1)
Anatomy Link Frequency
covering 1
skin 1
GRIA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate receptor 12 98.88 Very High Very High Very High
Serotonin 14 96.40 Very High Very High Very High
Migraine 46 91.76 High High
Inflammation 1 50.00 Quite Low
Glutamate 23 5.00 Very Low Very Low Very Low
adenocard 11 5.00 Very Low Very Low Very Low
depression 9 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Migraine With Aura 3 91.76 High High
Headache 45 80.76 Quite High
Epilepsy 14 76.28 Quite High
Targeted Disruption 7 67.52 Quite High
Inflammatory Pain 2 64.68 Quite High
INFLAMMATION 1 50.00 Quite Low
Neurodegenerative Disease 2 49.20 Quite Low
Stress 3 37.32 Quite Low
Motor Neuron Diseases 14 5.00 Very Low Very Low Very Low
Depression 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Considering that the T-allele is also the risk allele we can infer that nuclear factor/s bound to the region covering the -2012C>T polymorphism may function as positive regulator(s) for GRIA1 transcription.


Transcription (transcription) of GRIA1 in covering
1) Confidence 0.52 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.32 Pain Relevance 0.36
CONCLUSIONS: These results, in human tissue, demonstrate that iGluR mRNA and protein expression are increased during persistent inflammation and that this increased activity may be involved in mediating clinical inflammatory pain in human skin.


Transcription (expression) of iGluR in skin
2) Confidence 0.01 Published 2008 Journal Br J Anaesth Section Body Doc Link 18238837 Disease Relevance 0.06 Pain Relevance 0
These would include mRNA transcripts of the AMPA and kainate members of the glutamate receptor family – GluR-B, GluR-5 & GluR-6 [33], the serotonin 5-HT2C receptor [45], the ?
Transcription (transcripts) of AMPA associated with glutamate receptor and serotonin
3) Confidence 0.00 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 0.28 Pain Relevance 0.10

General Comments

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