INT149435

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Context Info
Confidence 0.30
First Reported 2004
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.55
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx1) plasma membrane (P2rx1) protein complex (P2rx1)
Anatomy Link Frequency
spinal cord 2
lamina 2
P2rx1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 17 100.00 Very High Very High Very High
Spinal cord 30 99.68 Very High Very High Very High
neuralgia 2 99.38 Very High Very High Very High
Glutamate 24 99.36 Very High Very High Very High
Neuropathic pain 7 99.04 Very High Very High Very High
primary afferent fibers 9 97.92 Very High Very High Very High
Dorsal horn neuron 6 96.84 Very High Very High Very High
Dorsal horn 28 95.40 Very High Very High Very High
ischemia 7 92.52 High High
agonist 11 87.12 High High
Disease Link Frequency Relevance Heat
Coronary Heart Disease 3 99.24 Very High Very High Very High
Neuropathic Pain 12 99.04 Very High Very High Very High
Nervous System Injury 6 98.12 Very High Very High Very High
Arrhythmia Under Development 2 93.28 High High
Cv Unclassified Under Development 5 92.52 High High
Coronary Artery Disease 2 90.76 High High
Death 1 79.76 Quite High
Neurological Disease 2 74.68 Quite High
Neurodegenerative Disease 1 71.44 Quite High
Depression 2 40.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fibronectin/integrin system is involved in P2X(4) receptor upregulation in the spinal cord and neuropathic pain after nerve injury.
Regulation (involved) of Positive_regulation (upregulation) of P2X in spinal cord associated with neuralgia, nervous system injury, neuropathic pain and spinal cord
1) Confidence 0.30 Published 2008 Journal Glia Section Title Doc Link 18240312 Disease Relevance 0.64 Pain Relevance 0.74
To this end, we have applied patch-clamp recording technique to the spinal cord slice preparations to assess the effects of P2X receptor activation on monosynaptic and polysynaptic transmission from primary afferent fibers to dorsal horn neurons located in a number of lamina regions.
Regulation (effects) of Positive_regulation (activation) of P2X in lamina associated with primary afferent fibers, dorsal horn neuron and spinal cord
2) Confidence 0.12 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096570 Disease Relevance 0 Pain Relevance 0.46
The pathological activation of CNS P2X receptors, regulating the release of glutamate during ischemic-like conditions, was also recently described [207].
Spec (like) Regulation (regulating) of Positive_regulation (activation) of P2X associated with glutamate and central nervous system
3) Confidence 0.10 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072919 Disease Relevance 0.92 Pain Relevance 0.47

General Comments

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