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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.50
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TWIST1) DNA binding (TWIST1) transcription factor binding (TWIST1)
Anatomy Link Frequency
embryos 1
spinal cord 1
TWIST1 (Homo sapiens)
Pain Link Frequency Relevance Heat
reflex sympathetic dystrophy 2 50.00 Quite Low
spinal-cord stimulation 2 50.00 Quite Low
Calcium channel 1 47.44 Quite Low
cytokine 5 5.00 Very Low Very Low Very Low
member 8 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Prostate Cancer 53 96.12 Very High Very High Very High
Complex Regional Pain Syndromes 4 89.92 High High
Pain 1 89.44 High High
Carcinoma 1 82.72 Quite High
Injury 11 77.96 Quite High
Cancer 49 76.72 Quite High
Apoptosis 8 71.56 Quite High
Metastasis 18 69.20 Quite High
Disease 17 63.12 Quite High
Toxicity 1 16.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Twenty-four patients who received SCS+PT also underwent placement of a permanent spinal cord stimulator after successful test stimulation; the remaining 12 patients did not receive a permanent stimulator.
Negative_regulation (received) of SCS in spinal cord
1) Confidence 0.41 Published 2008 Journal J. Neurosurg. Section Body Doc Link 18240925 Disease Relevance 0.18 Pain Relevance 0
Furthermore, inactivation of TWIST1, through small interfering RNA, induced growth arrest and suppressed migration and invasion abilities in androgen-independent PCa cell lines DU145 and PC3 [64], [65].
Negative_regulation (inactivation) of TWIST1 associated with prostate cancer
2) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.24 Pain Relevance 0
The number of SCs peaked at T72, at which time IL-6+ SCs had decreased close to baseline levels (<10% IL-6+ cells).
Negative_regulation (decreased) of SCs
3) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.08 Pain Relevance 0
When the total number of epidermal ICs and epidermal SCs was taken into account, there was no significant difference between mibta52b and sibling embryos (Figure 3D–3J).
Negative_regulation (number) of SCs in embryos
4) Confidence 0.01 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1810426 Disease Relevance 0 Pain Relevance 0

General Comments

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