INT149451

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.50
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Sstr5) plasma membrane (Sstr5) cytoplasm (Sstr5)
signal transducer activity (Sstr5)
Anatomy Link Frequency
pituitary 1
Sstr5 (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 103 100.00 Very High Very High Very High
agonist 35 100.00 Very High Very High Very High
dexamethasone 6 99.50 Very High Very High Very High
Dopamine 13 92.16 High High
Opioid 1 64.16 Quite High
dopamine receptor 2 63.28 Quite High
Onset of action 3 16.64 Low Low
antagonist 16 5.00 Very Low Very Low Very Low
imagery 15 5.00 Very Low Very Low Very Low
tolerance 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenoma 28 98.84 Very High Very High Very High
Apoptosis 3 91.40 High High
Cancer 75 83.88 Quite High
Acromegaly 48 83.12 Quite High
Pituitary Cancer 25 80.96 Quite High
Acth-secreting Pituitary Adenoma 21 71.52 Quite High
Pituitary Acth Hypersecretion 9 50.00 Quite Low
Hyperlipidemia 9 49.40 Quite Low
Hemorrhage 6 46.60 Quite Low
Gynecomastia 6 45.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GH secreting adenomas express different somatostatin receptors, as shown for example by a recent study in which 77% expressed SSTR2, 69% SSTR1 and SSTR3, and 60% SSTR5.
Gene_expression (expressed) of SSTR5 associated with adenoma and somatostatin
1) Confidence 0.39 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.83 Pain Relevance 0.13
More recently, it was found that sst5-targeting agonists were more effective than sst2-targeting agonists in inhibiting ACTH release; this could depend on dexamethasone decreasing sst2 but not sst5 expression.
Gene_expression (expression) of sst5 associated with agonist and dexamethasone
2) Confidence 0.32 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2963160 Disease Relevance 0.25 Pain Relevance 0.62
Rat pituitary corticotrophs express multiple somatostatin receptors (sst), including sst2 and sst5,49 but treatment of cultured rat corticotrophs with native SS-14 does not result in inhibition of ACTH release.50 However, SS-14 is able to decrease ACTH release when rat pituitary cells are cultured in glucocorticoid-free media.51 Therefore, it can be hypothesized that the presence of glucocorticoids reduces the inhibitory effects of native SS and traditional SS analogs on ACTH release through the down regulation of the SS binding sites.52 A number of studies have indicated that, in the murine AtT-20 cells, sst2 and sst5 are principally involved in the regulation of ACTH release.
Gene_expression (express) of sst5 in pituitary associated with somatostatin
3) Confidence 0.28 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2963160 Disease Relevance 0.18 Pain Relevance 0.60
More recently, it was found that sst5-targeting agonists were more effective than sst2-targeting agonists in inhibiting ACTH release; this could depend on dexamethasone decreasing sst2 but not sst5 expression.
Gene_expression (effective) of sst5-targeting associated with agonist and dexamethasone
4) Confidence 0.28 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2963160 Disease Relevance 0.24 Pain Relevance 0.66
Somatostatin acts through binding and activation of five G protein-coupled receptors (GPCRs) termed somatostatin receptors or ssts (sst1-sst5).
Gene_expression (receptors) of sst1-sst5 associated with somatostatin
5) Confidence 0.04 Published 2008 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 18242821 Disease Relevance 0 Pain Relevance 0.23

General Comments

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