INT149467

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Context Info
Confidence 0.55
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 4.73
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avpr1b) plasma membrane (Avpr1b) response to stress (Avpr1b)
signal transducer activity (Avpr1b)
Anatomy Link Frequency
plasma 1
Avpr1b (Mus musculus)
Pain Link Frequency Relevance Heat
Desipramine 2 99.40 Very High Very High Very High
fluoxetine 5 99.08 Very High Very High Very High
Neuropeptide 1 92.96 High High
tricyclic antidepressant 3 89.08 High High
sSRI 3 87.84 High High
depression 41 86.56 High High
antagonist 85 83.76 Quite High
antidepressant 8 75.00 Quite High
Serotonin 5 72.68 Quite High
agonist 45 52.40 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 305 99.96 Very High Very High Very High
Stress 402 96.04 Very High Very High Very High
Anxiety Disorder 40 87.84 High High
Depression 51 86.56 High High
Attention Deficit Hyperactivity Disorder 10 85.72 High High
Aggression 85 57.84 Quite High
Sprains And Strains 60 36.92 Quite Low
Overactive Bladder 5 24.24 Low Low
Neurogenic Diabetes Insipidus 5 22.40 Low Low
Obesity 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Table II, we find some acute and chronic stressors are not influenced by the loss of the Avpr1b (e.g. acute severe restraint), some have a reduced ACTH response only (e.g. acute forced swimming stress) and some have both a reduced ACTH and CORT response in Avpr1b KOs compared to wild types (e.g. acute and repeated novel environment stress).
Negative_regulation (loss) of Avpr1b associated with stress
1) Confidence 0.55 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.76 Pain Relevance 0.04
We cannot totally rule out the possibility that mechanisms compensating for the loss of Avpr1b are active in the Avpr1b KO.
Negative_regulation (loss) of Avpr1b associated with targeted disruption
2) Confidence 0.55 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.61 Pain Relevance 0
As far as HPA axis function is concerned, clearly Crh (or Oxt) does not compensate for the loss of the Avpr1b in Avpr1b KO mice.
Negative_regulation (loss) of Avpr1b associated with targeted disruption
3) Confidence 0.55 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 1.37 Pain Relevance 0.04
Nevertheless, stress-induced ACTH levels in our Avpr1b KOs are consistently lower (often to basal levels) than wild-type controls, confirming any compensation (e.g. from the action of Crh) is not sufficient to fully counteract the loss of the Avpr1b (Lolait et al. 2007a,b; Stewart et al. 2008a,b).
Negative_regulation (loss) of Avpr1b associated with stress
4) Confidence 0.41 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.55 Pain Relevance 0.03
Fluoxetine and desipramine administration significantly attenuated plasma ACTH and CORT levels in male and female Avpr1b KO mice when compared to their wild-type counterparts.
Negative_regulation (attenuated) of Avpr1b in plasma associated with targeted disruption, desipramine and fluoxetine
5) Confidence 0.40 Published 2008 Journal Psychoneuroendocrinology Section Abstract Doc Link 18243568 Disease Relevance 0.65 Pain Relevance 0.95
Prepulse inhibition of the startle reflex is attenuated in Avpr1b KO mice (Egashira et al. 2005) suggesting that this mouse may be a suitable model to investigate sensorimotor gating.
Negative_regulation (attenuated) of Avpr1b associated with targeted disruption
6) Confidence 0.35 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.79 Pain Relevance 0.10

General Comments

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