INT149473

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.64
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avp, Pomc) extracellular space (Avp, Pomc) extracellular region (Avp, Pomc)
generation of precursor metabolites and energy (Pomc) cell-cell signaling (Pomc) cytoplasm (Pomc)
Anatomy Link Frequency
pituitary 4
Avp (Mus musculus)
Pomc (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 17 96.32 Very High Very High Very High
depression 12 79.36 Quite High
Inflammatory mediators 1 75.12 Quite High
antidepressant 7 75.00 Quite High
sSRI 6 68.96 Quite High
tricyclic antidepressant 6 64.88 Quite High
Neuropeptide 11 56.52 Quite High
amygdala 9 54.96 Quite High
fluoxetine 10 47.04 Quite Low
Neurotransmitter 2 45.80 Quite Low
Disease Link Frequency Relevance Heat
Stress 112 98.92 Very High Very High Very High
Targeted Disruption 80 98.78 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 2 94.44 High High
Depression 14 79.36 Quite High
INFLAMMATION 4 74.72 Quite High
Increased Venous Pressure Under Development 1 73.16 Quite High
Body Weight 1 62.08 Quite High
Weight Loss 1 61.68 Quite High
Anxiety Disorder 12 46.72 Quite Low
Affective Disorder 3 27.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In times of stress the hypothalamic-pituitary-adrenal (HPA) axis is activated and releases two neurohormones, corticotropin-releasing hormone (Crh) and arginine vasopressin (Avp), to synergistically stimulate the secretion of adrenocorticotropin hormone (ACTH) from the anterior pituitary, culminating in a rise in circulating glucocorticoids.
vasopressin Positive_regulation (stimulate) of Localization (secretion) of ACTH in pituitary associated with stress
1) Confidence 0.48 Published 2008 Journal Psychoneuroendocrinology Section Abstract Doc Link 18243568 Disease Relevance 0.26 Pain Relevance 0.21
In times of stress the hypothalamic-pituitary-adrenal (HPA) axis is activated and releases two neurohormones, corticotropin-releasing hormone (Crh) and arginine vasopressin (Avp), to synergistically stimulate the secretion of adrenocorticotropin hormone (ACTH) from the anterior pituitary, culminating in a rise in circulating glucocorticoids.
Avp Positive_regulation (stimulate) of Localization (secretion) of ACTH in pituitary associated with stress
2) Confidence 0.37 Published 2008 Journal Psychoneuroendocrinology Section Abstract Doc Link 18243568 Disease Relevance 0.26 Pain Relevance 0.21
The studies in Avpr1b KO mice and Brattleboro rats highlight the discrepancy between Avp/Avpr1b-mediated ACTH and CORT secretion during acute and repeated stress—this may have implications on the potential use of Avpr1b antagonists to ameliorate symptoms of HPA axis hyperactivity in stress-related disorders.


Avp Positive_regulation (mediated) of Localization (secretion) of ACTH associated with stress, targeted disruption, antagonist and attention deficit hyperactivity disorder
3) Confidence 0.24 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 1.85 Pain Relevance 0.05
Of particular interest is the fact that vasopressin enhances this stimulatory effect of CRH on ACTH secretion (DeBold et al. 1984; Antoni, 1993).
vasopressin Positive_regulation (enhances) of Localization (secretion) of ACTH
4) Confidence 0.04 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.27 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox