INT149485

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Context Info
Confidence 0.60
First Reported 2007
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.39
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (C3) extracellular space (C3) extracellular region (C3)
Anatomy Link Frequency
blood 2
adipose tissue 2
C3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 5 99.98 Very High Very High Very High
agonist 3 80.76 Quite High
Inflammation 11 70.16 Quite High
Kinase C 1 65.44 Quite High
addiction 1 65.08 Quite High
cytokine 23 59.12 Quite High
opiate 1 57.12 Quite High
Neurobehavioral 1 54.56 Quite High
GABA receptor 5 32.72 Quite Low
gABA 3 28.76 Quite Low
Disease Link Frequency Relevance Heat
Flavivirus Infection 80 100.00 Very High Very High Very High
Necrosis 12 100.00 Very High Very High Very High
Afibrinogenemia 1 100.00 Very High Very High Very High
Hematological Disease 1 100.00 Very High Very High Very High
Obesity 65 99.62 Very High Very High Very High
Metabolic Disorder 5 96.04 Very High Very High Very High
Dengue 104 94.56 High High
Disease 139 92.68 High High
Infection 45 92.00 High High
Louse Infestation 1 78.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example the expression of the C3 protein, an acylation stimulating protein involved in necrosis and afibrinogenemia (blood disorders), has been shown to be affected by PA in rats [50].
Regulation (affected) of Gene_expression (expression) of C3 in blood associated with hematological disease, necrosis and afibrinogenemia
1) Confidence 0.60 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2873901 Disease Relevance 0.77 Pain Relevance 0.10
However, the C3 levels in DHF patients (1.0+/?
Regulation (1.0+) of Gene_expression (levels) of C3 associated with flavivirus infection
2) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 0.98 Pain Relevance 0
Taken together, this study illustrates that morphine modulates IL-1beta-mediated C3 expression in astrocytic cells.
Regulation (modulates) of Gene_expression (expression) of C3 associated with morphine
3) Confidence 0.24 Published 2008 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18247123 Disease Relevance 0.13 Pain Relevance 0.56
Moreover, fB and factor D (fD, adipsin) are produced by adipose tissue where they likely influence formation of the alternative pathway component C3 convertase and the production of the anaphylatoxin C3a and its carboxypeptidase B-anaphylatoxic–inactivated derivative C3adesArg (acylation-stimulating protein [ASP]).
Spec (likely) Regulation (influence) of Gene_expression (production) of C3 in adipose tissue associated with obesity
4) Confidence 0.16 Published 2010 Journal Diabetes Section Body Doc Link PMC2797922 Disease Relevance 1.26 Pain Relevance 0.06
As indicated in Table 4, little variation of C3 levels was observed in the course of the observation period; still, in three patient's a transitory decrease of its level below the standard laboratory range was observed.
Neg (little) Regulation (variation) of Gene_expression (levels) of C3
5) Confidence 0.16 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC3004381 Disease Relevance 0 Pain Relevance 0.03
Since the laboratory kits used were not the same in all centers, the normal values for anti-dsDNA, C3, and C4 levels differed among centers.
Regulation (values) of Gene_expression (levels) of C3
6) Confidence 0.13 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2659367 Disease Relevance 0.18 Pain Relevance 0

General Comments

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