INT149491

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.37
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PNOC, CD14) extracellular space (CD14) signal transduction (PNOC)
plasma membrane (CD14)
Anatomy Link Frequency
monocytes 4
PNOC (Homo sapiens)
CD14 (Homo sapiens)
Pain Link Frequency Relevance Heat
orphanin 14 100.00 Very High Very High Very High
chemokine 12 100.00 Very High Very High Very High
Inflammation 8 94.04 High High
Central nervous system 6 79.12 Quite High
Opioid 2 71.80 Quite High
agonist 2 54.16 Quite High
antagonist 2 53.12 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 6 94.04 High High
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results also demonstrate that nociceptin can suppress the production of CCL2/MCP-1 and CCL5/RANTES chemokine protein in both primary CD14(+) human monocytes and monocyte-like cell lines.
nociceptin Negative_regulation (suppress) of Gene_expression (production) of CD14 in monocytes associated with chemokine and orphanin
1) Confidence 0.40 Published 2008 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18247127 Disease Relevance 0.18 Pain Relevance 0.88
Our results also demonstrate that nociceptin can suppress the production of CCL2/MCP-1 and CCL5/RANTES chemokine protein in both primary CD14(+) human monocytes and monocyte-like cell lines.
nociceptin Negative_regulation (suppress) of in monocyte Gene_expression (production) of CD14 in monocytes associated with chemokine and orphanin
2) Confidence 0.14 Published 2008 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18247127 Disease Relevance 0.18 Pain Relevance 0.88

General Comments

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