INT149492

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 4
Disease Relevance 0.68
Pain Relevance 3.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PNOC, CCL2) extracellular region (PNOC, CCL2) extracellular space (CCL2)
aging (CCL2) cell adhesion (CCL2) cytoskeleton organization (CCL2)
Anatomy Link Frequency
monocytes 8
PNOC (Homo sapiens)
CCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
orphanin 28 100.00 Very High Very High Very High
Inflammation 16 100.00 Very High Very High Very High
chemokine 24 99.32 Very High Very High Very High
Opioid 4 98.20 Very High Very High Very High
Central nervous system 12 95.76 Very High Very High Very High
agonist 4 49.76 Quite Low
antagonist 4 48.72 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 12 94.04 High High
Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results also demonstrate that nociceptin can suppress the production of CCL2/MCP-1 and CCL5/RANTES chemokine protein in both primary CD14(+) human monocytes and monocyte-like cell lines.
nociceptin Negative_regulation (suppress) of Gene_expression (production) of CCL2/MCP-1 in monocytes associated with chemokine and orphanin
1) Confidence 0.15 Published 2008 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18247127 Disease Relevance 0.18 Pain Relevance 0.81
Suppression of CCL2/MCP-1 and CCL5/RANTES expression by nociceptin in human monocytes.
nociceptin Negative_regulation (Suppression) of Gene_expression (expression) of CCL2/MCP-1 in monocytes associated with inflammation and orphanin
2) Confidence 0.11 Published 2008 Journal J Neuroimmune Pharmacol Section Title Doc Link 18247127 Disease Relevance 0.16 Pain Relevance 0.77
Suppression of CCL2/MCP-1 and CCL5/RANTES expression by nociceptin in human monocytes.
nociceptin Negative_regulation (Suppression) of Gene_expression (expression) of CCL2/MCP-1 in monocytes associated with inflammation and orphanin
3) Confidence 0.11 Published 2008 Journal J Neuroimmune Pharmacol Section Title Doc Link 18247127 Disease Relevance 0.16 Pain Relevance 0.77
Our results also demonstrate that nociceptin can suppress the production of CCL2/MCP-1 and CCL5/RANTES chemokine protein in both primary CD14(+) human monocytes and monocyte-like cell lines.
nociceptin Negative_regulation (suppress) of in monocyte Gene_expression (production) of CCL2/MCP-1 in monocytes associated with chemokine and orphanin
4) Confidence 0.05 Published 2008 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18247127 Disease Relevance 0.18 Pain Relevance 0.81

General Comments

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