INT149494

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.52
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PNOC, CCL5) extracellular space (CCL5) signal transduction (PNOC)
aging (CCL5) cell-cell signaling (CCL5) cytoplasm (CCL5)
Anatomy Link Frequency
monocytes 6
PNOC (Homo sapiens)
CCL5 (Homo sapiens)
Pain Link Frequency Relevance Heat
orphanin 21 100.00 Very High Very High Very High
Inflammation 12 100.00 Very High Very High Very High
chemokine 18 99.96 Very High Very High Very High
Opioid 3 98.20 Very High Very High Very High
Central nervous system 9 95.76 Very High Very High Very High
agonist 3 51.04 Quite High
antagonist 3 50.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 9 94.04 High High
Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Suppression of CCL2/MCP-1 and CCL5/RANTES expression by nociceptin in human monocytes.
nociceptin Negative_regulation (Suppression) of Gene_expression (expression) of CCL5/RANTES in monocytes associated with inflammation and orphanin
1) Confidence 0.19 Published 2008 Journal J Neuroimmune Pharmacol Section Title Doc Link 18247127 Disease Relevance 0.16 Pain Relevance 0.77
Our results also demonstrate that nociceptin can suppress the production of CCL2/MCP-1 and CCL5/RANTES chemokine protein in both primary CD14(+) human monocytes and monocyte-like cell lines.
nociceptin Negative_regulation (suppress) of Gene_expression (production) of CCL5/RANTES in monocytes associated with chemokine and orphanin
2) Confidence 0.14 Published 2008 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18247127 Disease Relevance 0.18 Pain Relevance 0.84
Our results also demonstrate that nociceptin can suppress the production of CCL2/MCP-1 and CCL5/RANTES chemokine protein in both primary CD14(+) human monocytes and monocyte-like cell lines.
nociceptin Negative_regulation (suppress) of in monocyte Gene_expression (production) of CCL5/RANTES in monocytes associated with chemokine and orphanin
3) Confidence 0.05 Published 2008 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18247127 Disease Relevance 0.18 Pain Relevance 0.84

General Comments

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