INT1495

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.54
First Reported 1977
Last Reported 2011
Negated 3
Speculated 2
Reported most in Abstract
Documents 91
Total Number 93
Disease Relevance 22.93
Pain Relevance 32.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rtcd1) molecular_function (Rtcd1) ligase activity (Rtcd1)
Anatomy Link Frequency
platelet 4
neurons 4
spinal cord 3
tail 2
nerves 2
Rtcd1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 250 100.00 Very High Very High Very High
agonist 96 100.00 Very High Very High Very High
opiate 33 100.00 Very High Very High Very High
Dopamine 20 100.00 Very High Very High Very High
noradrenaline 12 100.00 Very High Very High Very High
nMDA receptor 10 100.00 Very High Very High Very High
Morphine 53 99.98 Very High Very High Very High
Neurotransmitter 16 99.92 Very High Very High Very High
Kinase C 6 99.84 Very High Very High Very High
opioid receptor 11 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 6 99.92 Very High Very High Very High
Vibrio Infection 33 99.86 Very High Very High Very High
Neuroblastoma 11 99.84 Very High Very High Very High
Spasticity 10 99.84 Very High Very High Very High
Experimental Melanoma 2 99.76 Very High Very High Very High
Ganglion Cysts 25 99.68 Very High Very High Very High
Hypoxia 10 99.68 Very High Very High Very High
Malignant Neoplastic Disease 4 99.36 Very High Very High Very High
Cv Unclassified Under Development 22 99.24 Very High Very High Very High
Glioma 10 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Guanylate cyclase activation by azide required added catalase, and both enzyme activation and hepatic cyclic GMP formation were inhibited by aminotriazole.
Positive_regulation (activation) of cyclase
1) Confidence 0.54 Published 1987 Journal J. Biol. Chem. Section Abstract Doc Link 2435723 Disease Relevance 0 Pain Relevance 0.08
The same factors that regulate the activation of purified hepatic soluble guanylate cyclase by diverse agents possessing distinct requirements for enzyme activation were found to modulate cyclic GMP formation in intact viable hepatic cells.
Positive_regulation (activation) of cyclase
2) Confidence 0.54 Published 1987 Journal J. Biol. Chem. Section Abstract Doc Link 2435723 Disease Relevance 0 Pain Relevance 0
A comparison was made between activation of heme-deficient or heme-reconstituted guanylate cyclase and stimulation of cyclic GMP formation in mouse hepatic slices that were 95% viable and showed no active efflux of cyclic GMP.
Positive_regulation (activation) of cyclase
3) Confidence 0.54 Published 1987 Journal J. Biol. Chem. Section Abstract Doc Link 2435723 Disease Relevance 0 Pain Relevance 0
Hepatic cyclic GMP formation is regulated by similar factors that modulate activation of purified hepatic soluble guanylate cyclase.
Positive_regulation (activation) of cyclase
4) Confidence 0.54 Published 1987 Journal J. Biol. Chem. Section Title Doc Link 2435723 Disease Relevance 0 Pain Relevance 0
It must be assumed that intracellular changes in the target organ which are associated with a diminished responsiveness for guanylate cyclase activation are at the basis of tolerance development.
Positive_regulation (activation) of cyclase associated with tolerance
5) Confidence 0.45 Published 1986 Journal Z Kardiol Section Abstract Doc Link 3541418 Disease Relevance 0.07 Pain Relevance 0.40
G-proteins that inhibit adenylate cyclase activity mediate the activity of the 5-HT2B receptor subunit, which is widely expressed in a variety of tissues, including liver, lung, heart, and coronary and pulmonary arteries; it has also been reported in embryonic mouse heart, particularly on mouse heart valve leaflets.
Positive_regulation (mediate) of cyclase in liver
6) Confidence 0.43 Published 2009 Journal J Am Soc Echocardiogr Section Abstract Doc Link 19553085 Disease Relevance 0.63 Pain Relevance 0.39
Heme-dependent activators of guanylate cyclase elicited a greater -fold increase in hepatic cyclic GMP levels in slices from phenobarbital-pretreated than control mice.
Positive_regulation (activators) of cyclase
7) Confidence 0.39 Published 1987 Journal J. Biol. Chem. Section Abstract Doc Link 2435723 Disease Relevance 0 Pain Relevance 0
Nicorandil and new compounds containing nitro groups have a dual mechanism of action, also activating guanylate cyclase, an effect that contributes to their cardiovascular effect profile.
Positive_regulation (activating) of cyclase
8) Confidence 0.34 Published 1992 Journal Pharmacol. Toxicol. Section Abstract Doc Link 1535127 Disease Relevance 0.24 Pain Relevance 0.12
We suggest that macrophage opioid receptors signaling switches from a Gi/o-mediated mechanism that does not involve adenylate cyclase in acute exposure to a non-Gi/o-mediated adenylate cyclase superactivation during chronic exposure.
Positive_regulation (superactivation) of cyclase in macrophage associated with opioid receptor
9) Confidence 0.29 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16750574 Disease Relevance 0.07 Pain Relevance 0.61
An enhanced response of the NA-sensitive adenylate cyclase to 1-NA(10-5 M), in comparison to control mice, was demonstrated after treatments producing a chronic reduction in stimulation of alpha-adrenergic receptors (phenoxybenzamine 10 mg/kg per day), beta-adrenergic receptors (propranolol, 0.05% diet), all noradrenergic receptors (reserpine 5 mg/kg, followed by FLA-63, 25 mg/kg per day), and dopaminergic as well as noradrenergic receptors (chlorpromazine, 5 mg/kg per day).
Positive_regulation (response) of cyclase associated with noradrenaline
10) Confidence 0.27 Published 1977 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 909612 Disease Relevance 0 Pain Relevance 0.31
Postnatally with a substantial increase in Gpp[NH]p stimulated adenylyl cyclase activity, the small form (Gs.s) increased in amount while Gs-1 decreased.
Positive_regulation (increase) of cyclase
11) Confidence 0.16 Published 1991 Journal FEBS Lett. Section Abstract Doc Link 1652479 Disease Relevance 0 Pain Relevance 0.08
The activation of adenylate cyclase due to anoxia is considered as one of the initial steps in the cell injury extention.
Positive_regulation (activation) of cyclase associated with hypoxia and injury
12) Confidence 0.16 Published 1981 Journal Tsitologiia Section Abstract Doc Link 6266087 Disease Relevance 0.67 Pain Relevance 0.12
It was first demonstrated that carnosine is a selective inhibitor of NO-dependent activation of guanylate cyclase and may be used for suppression of activity of the intracellular signaling system NO-soluble guanylate cyclase-cGMP, whose sharp increase is observed in malignant tumors, sepsis, septic shock, asthma, and migraine.
Neg (NO) Positive_regulation (activation) of cyclase associated with asthma, malignant neoplastic disease, migraine and sepsis
13) Confidence 0.16 Published 2000 Journal Biochemistry Mosc. Section Abstract Doc Link 10951096 Disease Relevance 0.46 Pain Relevance 0.09
It was first demonstrated that carnosine is a selective inhibitor of NO-dependent activation of guanylate cyclase and may be used for suppression of activity of the intracellular signaling system NO-soluble guanylate cyclase-cGMP, whose sharp increase is observed in malignant tumors, sepsis, septic shock, asthma, and migraine.
Positive_regulation (increase) of cyclase associated with asthma, malignant neoplastic disease, migraine and sepsis
14) Confidence 0.16 Published 2000 Journal Biochemistry Mosc. Section Abstract Doc Link 10951096 Disease Relevance 0.49 Pain Relevance 0.10
It is shown that carnosine inhibits the activation of soluble guanylate cyclase by sodium nitroprusside and a derivative of furoxan--1,2,5-oxadiazolo-trioxide (an NO donor).
Positive_regulation (activation) of cyclase
15) Confidence 0.16 Published 2000 Journal Biochemistry Mosc. Section Abstract Doc Link 10951096 Disease Relevance 0 Pain Relevance 0
G-proteins that inhibit adenylate cyclase activity mediate the activity of the 5-HT2B receptor subunit, which is widely expressed in a variety of tissues, including liver, lung, heart, and coronary and pulmonary arteries; it has also been reported in embryonic mouse heart, particularly on mouse heart valve leaflets.
Positive_regulation (mediate) of cyclase in heart
16) Confidence 0.15 Published 2009 Journal J Am Soc Echocardiogr Section Abstract Doc Link 19553085 Disease Relevance 0.63 Pain Relevance 0.39
G-proteins that inhibit adenylate cyclase activity mediate the activity of the 5-HT2B receptor subunit, which is widely expressed in a variety of tissues, including liver, lung, heart, and coronary and pulmonary arteries; it has also been reported in embryonic mouse heart, particularly on mouse heart valve leaflets.
Positive_regulation (mediate) of cyclase in lung
17) Confidence 0.15 Published 2009 Journal J Am Soc Echocardiogr Section Abstract Doc Link 19553085 Disease Relevance 0.63 Pain Relevance 0.39
The inhibition by carnosine of guanylate cyclase activation by an NO donor is due to the interaction of carnosine with heme iron with subsequent formation of a chelate complex.
Positive_regulation (activation) of cyclase
18) Confidence 0.12 Published 2000 Journal Biochemistry Mosc. Section Abstract Doc Link 10951096 Disease Relevance 0 Pain Relevance 0.07
Withdrawal of the receptor ligand then results in relatively long-lived increases in adenylate cyclase activity and intracellular cAMP levels.
Positive_regulation (increases) of cyclase associated with withdrawal
19) Confidence 0.12 Published 1978 Journal Natl Cancer Inst Monogr Section Abstract Doc Link 219360 Disease Relevance 0.25 Pain Relevance 0.34
Growth of cells for 12--48 hours in the presence of a receptor--activator gradually results in a compensatory increase in adenylate cyclase activity.
Positive_regulation (increase) of cyclase
20) Confidence 0.12 Published 1978 Journal Natl Cancer Inst Monogr Section Abstract Doc Link 219360 Disease Relevance 0.25 Pain Relevance 0.34

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox