INT149506

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.83
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hist1h1t) chromosome (Hist1h1t) nucleus (Hist1h1t)
intracellular (Hist1h1t) DNA binding (Hist1h1t)
Anatomy Link Frequency
paw 1
Hist1h1t (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 5 79.12 Quite High
analgesia 2 50.00 Quite Low
Visceral pain 2 50.00 Quite Low
opioid receptor 2 50.00 Quite Low
Inflammation 2 25.00 Low Low
Pain 2 25.00 Low Low
Analgesic 2 10.00 Low Low
Endogenous opioid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 3 97.44 Very High Very High Very High
Nociception 6 96.86 Very High Very High Very High
Inflammatory Pain 3 79.12 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both nociceptive flinching and hind paw edema induced by injection of 5% formalin were attenuated by pretreatment with DL-propargylglycine (PPG; 50 mg/kg, i.p.) which is an inhibitor of the H2S synthesizing enzyme cystathionine-gamma-lyase (CSE).
Negative_regulation (inhibitor) of H2S in paw associated with nociception and pressure and volume under development
1) Confidence 0.30 Published 2008 Journal Neuroscience Section Abstract Doc Link 18248901 Disease Relevance 0.83 Pain Relevance 0.18
By pharmacological and molecular analyses, a robust inhibition of H2S-induced analgesia was observed in response to central administration of CTAP and MOR antisense, while kappa and delta receptors were less involved.
Negative_regulation (inhibition) of H2S
2) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link 20540729 Disease Relevance 0 Pain Relevance 0

General Comments

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