INT149507

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.71
Pain Relevance 2.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hist1h1t) chromosome (Hist1h1t) nucleus (Hist1h1t)
intracellular (Hist1h1t) DNA binding (Hist1h1t)
Anatomy Link Frequency
paw 1
Hist1h1t (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 131 99.44 Very High Very High Very High
IPN 1 97.48 Very High Very High Very High
Antinociceptive 7 97.02 Very High Very High Very High
Eae 10 96.68 Very High Very High Very High
antagonist 37 96.28 Very High Very High Very High
Hyperalgesia 3 95.92 Very High Very High Very High
qutenza 1 87.76 High High
Analgesic 18 86.80 High High
Neurotransmitter 2 84.16 Quite High
analgesia 20 84.12 Quite High
Disease Link Frequency Relevance Heat
Nociception 25 99.04 Very High Very High Very High
Inflammatory Pain 7 97.48 Very High Very High Very High
Hyperalgesia 3 95.92 Very High Very High Very High
Pressure And Volume Under Development 6 87.84 High High
INFLAMMATION 10 82.28 Quite High
Pain 19 81.60 Quite High
Syndrome 2 68.96 Quite High
Dyspepsia 22 67.76 Quite High
Functional Bowel Disorder 3 51.84 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

40 49.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased concentration of H2S was found in homogenates prepared from hind paws injected with 5% (but not 1.25%) formalin.
Positive_regulation (Increased) of H2S
1) Confidence 0.26 Published 2008 Journal Neuroscience Section Abstract Doc Link 18248901 Disease Relevance 0.74 Pain Relevance 0.17
Hind paw injection of formalin evoked a concentration-dependent increase in the hind paw concentration of H2S.
Positive_regulation (increase) of H2S in paw
2) Confidence 0.21 Published 2008 Journal Neuroscience Section Abstract Doc Link 18248901 Disease Relevance 0.73 Pain Relevance 0.17
Further, H2S generation is also enhanced in the formalin [12] and carrageenan [13] model of persistent inflammatory pain.
Positive_regulation (enhanced) of H2S associated with ipn
3) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 1.11 Pain Relevance 0.76
In addition to specific pharmacological antagonism exerted in vivo by CTAP and MOR antisense on antinociceptive activity of H2S, results from in vitro pharmacological dissection of signaling pathways activated by H2S are consistent in supporting the view that H2S transactivates the ?
Positive_regulation (transactivates) of H2S associated with antagonist, opioid receptor and antinociceptive
4) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0.13 Pain Relevance 1.23

General Comments

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