INT149510

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Context Info
Confidence 0.56
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.74
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) transport (Trpv1) plasma membrane (Trpv1)
transmembrane transport (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
sensory neurons 2
neuronal 2
spinal cord 2
Trpv1 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 118 100.00 Very High Very High Very High
agonist 22 98.92 Very High Very High Very High
Spinal cord 3 98.16 Very High Very High Very High
IPN 4 97.84 Very High Very High Very High
TRP channel 2 93.56 High High
imagery 14 91.44 High High
trigeminal ganglion 75 89.12 High High
Sciatic nerve 32 88.52 High High
qutenza 38 86.56 High High
Inflammation 2 76.48 Quite High
Disease Link Frequency Relevance Heat
Cold Sores 272 100.00 Very High Very High Very High
Ganglion Cysts 214 100.00 Very High Very High Very High
Targeted Disruption 28 98.16 Very High Very High Very High
Inflammatory Pain 4 97.84 Very High Very High Very High
Overactive Bladder 15 80.52 Quite High
INFLAMMATION 2 76.48 Quite High
Toxicity 4 75.84 Quite High
Hypothermia 1 73.12 Quite High
Neuropathic Pain 6 57.28 Quite High
Hypersensitivity 3 56.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantitative RT-PCR revealed that TRPV1 mRNA levels in the DRG of animals injected with HSV-U6shTRPV1 were reduced by 53.6 ± 11.2% (mean ± SD) compared to the right DRG.
Negative_regulation (reduced) of Transcription (levels) of TRPV1 associated with dorsal root ganglion and cold sores
1) Confidence 0.56 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2504301 Disease Relevance 1.60 Pain Relevance 0.50
Our results demonstrate a significant reduction in Trpv1 mRNA levels in sensory neurons from mice injected with the vector expressing shTRPV1 and 59% reduction in TrpV1 protein levels following injection of the vector expressing miR-TRPV1.
Negative_regulation (reduction) of Transcription (levels) of Trpv1 in sensory neurons
2) Confidence 0.56 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2504301 Disease Relevance 0.84 Pain Relevance 0.29
Expression of shRNAs targeting TRPV1 in transgenic (tg) mice was proven by RNase protection assays, and TRPV1 downregulation was confirmed by reduced expression of TRPV1 mRNA and lack of receptor agonist binding in spinal cord membranes.
Negative_regulation (reduced) of Transcription (expression) of TRPV1 in spinal cord associated with targeted disruption, agonist and spinal cord
3) Confidence 0.43 Published 2008 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 18249134 Disease Relevance 0.68 Pain Relevance 0.32
Quantitative polymerase chain reaction showed very low levels of TRPA1 and TRPV1 mRNA but high levels of TRPV4 and TRPV2 mRNA.
Negative_regulation (levels) of Transcription (levels) of TRPV1
4) Confidence 0.36 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948364 Disease Relevance 0.25 Pain Relevance 0.13
For real time PCR, the relative mRNA expression of P2X3, P2X2 and TRPV1 in the different samples was normalized to the neuronal ?
Negative_regulation (relative) of Transcription (expression) of TRPV1 in neuronal
5) Confidence 0.24 Published 2006 Journal Mol Pain Section Body Doc Link PMC1448213 Disease Relevance 0.38 Pain Relevance 0.26

General Comments

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