INT149512

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.48
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpv3)
Anatomy Link Frequency
peripheral nerves 2
brachial plexus 2
Trpv3 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 15 98.96 Very High Very High Very High
agonist 65 98.04 Very High Very High Very High
Pain 185 97.32 Very High Very High Very High
qutenza 49 96.16 Very High Very High Very High
Dorsal horn 24 88.28 High High
analgesia 20 77.28 Quite High
Pain management 2 71.68 Quite High
antagonist 74 69.68 Quite High
allodynia 15 66.88 Quite High
nociceptor 92 65.28 Quite High
Disease Link Frequency Relevance Heat
Injury 4 98.88 Very High Very High Very High
Targeted Disruption 52 98.68 Very High Very High Very High
Pain 193 97.32 Very High Very High Very High
Ganglion Cysts 4 89.40 High High
Cancer 8 86.68 High High
Alopecia 2 84.96 Quite High
Hypothermia 1 82.72 Quite High
Neuropathic Pain 44 66.88 Quite High
Hypersensitivity 7 65.76 Quite High
Hyperalgesia 54 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unexpectedly, TRPV3 mRNA expression was upregulated in shRNAtg but downregulated in knockout mice.
Positive_regulation (upregulated) of Gene_expression (expression) of TRPV3 associated with targeted disruption
1) Confidence 0.49 Published 2008 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 18249134 Disease Relevance 0.78 Pain Relevance 0.45
One study showed an increase in TRPV3 expression following brachial plexus avulsion, however, its symptoms are not pain related [190].
Positive_regulation (increase) of Gene_expression (expression) of TRPV3 in brachial plexus associated with pain
2) Confidence 0.23 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.87 Pain Relevance 0.51
However, an increase in TRPV3 expression in peripheral nerves after injury and in avulsed DRG is documented [60].
Positive_regulation (increase) of Gene_expression (expression) of TRPV3 in peripheral nerves associated with injury
3) Confidence 0.15 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.83 Pain Relevance 0.60

General Comments

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