INT149513

Context Info Confidence 0.53 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.79 Pain Relevance 0.59

transport (Trpv3)

Trpv3 (Mus musculus)

Pain Link Frequency Relevance Heat Spinal cord 1 98.96 qutenza 5 98.48 agonist 1 98.04 Nerve growth factor 1 83.60 allodynia 1 69.20 fifth nerve 2 62.40 Neuropathic pain 1 60.72 Pain 1 52.40 TRP channel 13 50.00 Central nervous system 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 9 99.84 Hypothermia 1 85.04 Neuropathic Pain 2 69.20 Hypersensitivity 1 68.08 Brain Injury 2 25.08 Loss Of Sense Of Smell 4 24.08 Apoptosis 2 10.60 Death 3 8.92 Necrosis 1 5.00 Injury 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the pathological condition, the expression of TRPV3, TRPV4, TRPM5, and TRPA1 was markedly reduced and recovery took a long time.

Negative_regulation (reduced) of Gene_expression (expression) of TRPV3

1) Confidence 0.53 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0 Pain Relevance 0.13

Unexpectedly, TRPV3 mRNA expression was upregulated in shRNAtg but downregulated in knockout mice.

Negative_regulation (downregulated) of Gene_expression (expression) of TRPV3 associated with targeted disruption

2) Confidence 0.41 Published 2008 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 18249134 Disease Relevance 0.79 Pain Relevance 0.47

General Comments

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