INT149518

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Context Info
Confidence 0.62
First Reported 2005
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 6.73
Pain Relevance 9.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NAV1) cytoplasm (NAV1)
Anatomy Link Frequency
nerve 5
neuron 4
dorsal root ganglia 2
teeth 1
NAV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nav1.7 319 100.00 Very High Very High Very High
sodium channel 92 100.00 Very High Very High Very High
nav1.8 73 100.00 Very High Very High Very High
Nav1.9 21 100.00 Very High Very High Very High
dorsal root ganglion 54 99.84 Very High Very High Very High
Pain 356 99.52 Very High Very High Very High
hyperexcitability 20 99.40 Very High Very High Very High
IPN 31 97.80 Very High Very High Very High
Inflammation 45 95.72 Very High Very High Very High
Inflammatory mediators 3 90.76 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 67 99.84 Very High Very High Very High
Breast Cancer 4 99.60 Very High Very High Very High
Pain 248 99.52 Very High Very High Very High
Burning Mouth Syndrome 117 99.28 Very High Very High Very High
Reprotox - General 1 2 98.72 Very High Very High Very High
Inflammatory Pain 31 97.80 Very High Very High Very High
INFLAMMATION 45 95.72 Very High Very High Very High
Carcinoma 1 89.20 High High
Neuropathic Pain 63 87.68 High High
Toothache 9 86.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is unlikely that extracting teeth, or taking tongue biopsies, under local or general anaesthesia will affect Nav channel expression; the acute effects of anaesthetics would not be expected to alter Nav channel levels in the short term, as Nav channels are synthesized in cell bodies and axonally transport to the nerve terminals where they are inserted into membranes, a process with a turnover of several days.
Regulation (affect) of in nerve Gene_expression (expression) of Nav in teeth
1) Confidence 0.62 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2890014 Disease Relevance 0.62 Pain Relevance 1.03
The expression of Nav1.7 sodium channel in sub-epithelial nerve fibres did not change significantly in BMS in this study.
Neg (not) Regulation (change) of Gene_expression (expression) of Nav1 in nerve associated with burning mouth syndrome, sodium channel and nav1.7
2) Confidence 0.45 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2890014 Disease Relevance 1.93 Pain Relevance 1.61
CP, ST and CB were responsible for the design and production of the NaV1.8 antibodies used, help with interpretation of the data, and writing the manuscript.
Regulation (responsible) of Gene_expression (production) of NaV1
3) Confidence 0.45 Published 2005 Journal BMC Oral Health Section Body Doc Link PMC1183220 Disease Relevance 0.60 Pain Relevance 1.02
Transition from the immature to a mature differentiation state, however, was accompanied by the down-regulation of Nav1.7 expression concomitant with the up-regulation of voltage-gated Kv1.3 K+ channel expression.
Regulation (regulation) of Gene_expression (expression) of Nav1 associated with nav1.7
4) Confidence 0.45 Published 2009 Journal J. Immunol. Section Abstract Doc Link 19748986 Disease Relevance 0 Pain Relevance 0.23
Quantitative analysis of Nav1.7 expression in N52/PGP9.5-identified nerve area
Regulation (analysis) of Gene_expression (expression) of Nav1 in nerve associated with nav1.7
5) Confidence 0.45 Published 2008 Journal Mol Pain Section Body Doc Link PMC2377237 Disease Relevance 0 Pain Relevance 0.94
Strickland et al. (2008) investigated the changes in expression of Nav1.7, Nav1.8 and Nav1.9 sodium channels in the rat model and showed that the dorsal root ganglia innervating the knee joint had increased expression of all three subtypes up to 28 days after the initial insult [30].
Spec (investigated) Regulation (changes) of Spec (investigated) Gene_expression (expression) of Nav1 in dorsal root ganglia associated with sodium channel, nav1.8, nav1.7 and nav1.9
6) Confidence 0.27 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2890014 Disease Relevance 0.93 Pain Relevance 1.67
To investigate the mechanisms regulating physiological and pathophysiological Nav1.7 expression we identified the core promoter of this gene (SCN9A) in the human genome.
Spec (investigate) Regulation (regulating) of Gene_expression (expression) of Nav1 associated with nav1.7
7) Confidence 0.25 Published 2008 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 18249135 Disease Relevance 0.20 Pain Relevance 0.45
Protein kinase A and regulation of neonatal Nav1.5 expression in human breast cancer cells: activity-dependent positive feedback and cellular migration.
Regulation (regulation) of Gene_expression (expression) of Nav1 associated with breast cancer
8) Confidence 0.25 Published 2010 Journal Int. J. Biochem. Cell Biol. Section Title Doc Link 19948241 Disease Relevance 0.40 Pain Relevance 0.18
These data suggest that ranolazine may be useful for treatment of some pain conditions in which up-regulated Nav1.7 expression, or modulation of this channel, contributes to DRG neuron hyperexcitability (see [11,12,19]).
Regulation (contributes) of Gene_expression (expression) of Nav1 in neuron associated with dorsal root ganglion, pain, hyperexcitability and nav1.7
9) Confidence 0.14 Published 2010 Journal Mol Pain Section Body Doc Link PMC2898769 Disease Relevance 1.04 Pain Relevance 1.24
These data suggest that ranolazine may be useful for treatment of some pain conditions in which up-regulated Nav1.7 expression, or modulation of this channel, contributes to DRG neuron hyperexcitability (see [11,12,19]).
Regulation (regulated) of Gene_expression (expression) of Nav1 in neuron associated with dorsal root ganglion, pain, hyperexcitability and nav1.7
10) Confidence 0.14 Published 2010 Journal Mol Pain Section Body Doc Link PMC2898769 Disease Relevance 1.02 Pain Relevance 1.24

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