INT149553

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.29
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) cytoplasmic membrane-bounded vesicle (Cxcr4) plasma membrane (Cxcr4)
signal transducer activity (Cxcr4)
Anatomy Link Frequency
satellite cells 2
Cxcr4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 62 97.68 Very High Very High Very High
dorsal root ganglion 42 96.76 Very High Very High Very High
MU agonist 2 85.40 High High
Enkephalin 1 83.56 Quite High
cytokine 5 78.84 Quite High
Opioid 2 74.16 Quite High
Peripheral nerve injury 3 71.28 Quite High
Morphine 1 68.32 Quite High
opioid receptor 1 67.36 Quite High
Neuropathic pain 12 47.00 Quite Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 42 96.76 Very High Very High Very High
Nervous System Injury 8 71.28 Quite High
Injury 33 56.68 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 21 50.00 Quite Low
Neuropathic Pain 16 47.00 Quite Low
Nociception 7 13.64 Low Low
Neuropathy 13 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 10 5.00 Very Low Very Low Very Low
Hyperalgesia 5 5.00 Very Low Very Low Very Low
Peripheral Neuropathy 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Notably satellite cells under these conditions lacked both CXCR4 mRNA transcripts and protein expression (Fig. 4E, F).
Negative_regulation (lacked) of Transcription (expression) of CXCR4 mRNA in satellite cells
1) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.29 Pain Relevance 0.18
Similarly, pretreatment with cycloheximide prevented CCL5 or CXCR4 mRNA expression, consistent with the observation that DAMGO induction of chemokine and chemokine receptor expression requires newly synthesized TGF-beta1 protein.
Negative_regulation (prevented) of Transcription (expression) of CXCR4 associated with chemokine
2) Confidence 0.09 Published 2008 Journal J. Leukoc. Biol. Section Abstract Doc Link 18252865 Disease Relevance 0 Pain Relevance 0.88

General Comments

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