INT149594

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.89
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lif) extracellular region (Lif)
Anatomy Link Frequency
neurons 2
Lif (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 7 97.00 Very High Very High Very High
cytokine 34 87.12 High High
Nerve growth factor 4 83.92 Quite High
Root ganglion neuron 2 81.88 Quite High
Neuropathic pain 1 64.00 Quite High
Thermal hyperalgesia 1 62.56 Quite High
ischemia 14 5.00 Very Low Very Low Very Low
antagonist 10 5.00 Very Low Very Low Very Low
Glutamate 8 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 2 92.92 High High
Injury 70 84.68 Quite High
Ganglion Cysts 2 81.56 Quite High
Leukemia 2 75.00 Quite High
Nervous System Injury 1 73.44 Quite High
Death 12 65.88 Quite High
Neuropathic Pain 1 64.00 Quite High
Hyperalgesia 1 62.56 Quite High
Infection 6 20.64 Low Low
Retroviridae Infections 2 15.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the absence of LIF, within the population of heat-sensitive neurons, the proportion of neurons also GAL-IR increased from 17% to 32% between 6h and 1 day in culture to stay at this level.
Positive_regulation (increased) of Neg (absence) Gene_expression (absence) of LIF in neurons
1) Confidence 0.47 Published 2008 Journal Neuropeptides Section Abstract Doc Link 18258298 Disease Relevance 0.66 Pain Relevance 0.85
1, as compared to those treated with LIF alone or with EGF or TGF?
Positive_regulation (treated) of Gene_expression (treated) of LIF
2) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832687 Disease Relevance 0 Pain Relevance 0.06
Gene array analysis validated by QRT-PCR revealed an increase in the expression of LIF and TGFß1 as well as their corresponding receptors, LIFR, gp130 and AK5 in the SVZ at 7 days recovery from H/I.
Positive_regulation (increase) of Gene_expression (expression) of LIF
3) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832687 Disease Relevance 0.23 Pain Relevance 0.09

General Comments

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