INT14960

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Context Info
Confidence 0.68
First Reported 1984
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 20
Disease Relevance 12.71
Pain Relevance 3.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpinc1)
Anatomy Link Frequency
plasma 6
blood 2
liver 1
platelet 1
red blood cell 1
Serpinc1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 1 100.00 Very High Very High Very High
headache 9 98.36 Very High Very High Very High
abdominal pain 2 98.14 Very High Very High Very High
rheumatoid arthritis 1 97.28 Very High Very High Very High
Angina 9 96.96 Very High Very High Very High
aspirin 5 96.68 Very High Very High Very High
anesthesia 10 94.04 High High
Pain 2 93.48 High High
Arthritis 1 93.36 High High
Chronic pancreatitis 5 92.08 High High
Disease Link Frequency Relevance Heat
Cancer 4 100.00 Very High Very High Very High
Thrombocytopenia 3 100.00 Very High Very High Very High
Hemorrhage 48 99.40 Very High Very High Very High
Disseminated Intravascular Coagulation 4 99.20 Very High Very High Very High
Hematoma 148 99.12 Very High Very High Very High
Coronary Artery Disease 13 98.40 Very High Very High Very High
Headache 6 98.36 Very High Very High Very High
Abdominal Pain 2 98.14 Very High Very High Very High
Proteinuria 2 97.30 Very High Very High Very High
Rheumatoid Arthritis 1 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bleeding tendency possibly related to increased plasma antithrombin III activity in patient treated with piroxicam.
Positive_regulation (increased) of antithrombin III in plasma associated with hemorrhage
1) Confidence 0.68 Published 1984 Journal South. Med. J. Section Title Doc Link 6609435 Disease Relevance 0.38 Pain Relevance 0.14
This phenomenon of heparin resistance was postulated to be due to consumption of circulating antithrombin III as a result of prior heparinisation.
Positive_regulation (circulating) of antithrombin III
2) Confidence 0.49 Published 1998 Journal Ann. Acad. Med. Singap. Section Abstract Doc Link 10101569 Disease Relevance 0.18 Pain Relevance 0.09
The background and significance for the decrease in antithrombin III activity induced by n-3 and n-6 PUFA's in patients with ischaemic heart disease is unknown.
Positive_regulation (induced) of antithrombin III in heart associated with coronary artery disease
3) Confidence 0.46 Published 1988 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 3060987 Disease Relevance 0.25 Pain Relevance 0.15
Plasma samples collected from rat liver donors that had received DES showed similar effects on protein concentrations: significant decreases in concentration of plasminogen and antithrombin III were apparent with no significant changes in concentrations of fibrinogen, fibronectin, or albumin.
Positive_regulation (concentration) of antithrombin III in liver
4) Confidence 0.33 Published 1985 Journal Blood Section Abstract Doc Link 4016277 Disease Relevance 0 Pain Relevance 0.07
However, the mean activity in plasma of antithrombin III (but not the level of antithrombin III antigen) was significantly lower in patients of group II compared with group I.
Positive_regulation (level) of antithrombin III in plasma
5) Confidence 0.17 Published 1984 Journal Circulation Section Abstract Doc Link 6689640 Disease Relevance 0.45 Pain Relevance 0.07
However, the mean activity in plasma of antithrombin III (but not the level of antithrombin III antigen) was significantly lower in patients of group II compared with group I.
Positive_regulation (level) of antithrombin III in plasma
6) Confidence 0.17 Published 1984 Journal Circulation Section Abstract Doc Link 6689640 Disease Relevance 0.45 Pain Relevance 0.07
Ticlopidine and aspirin/dipyridamole, but not xanthinol nicotinate, improved platelet aggregation, reduced beta-thromboglobulin, platelet factor IV and fibrinopeptide A concentrations, and increased antithrombin III concentrations and red blood cell filterability.
Positive_regulation (increased) of antithrombin III in red blood cell associated with aspirin
7) Confidence 0.09 Published 1990 Journal J. Int. Med. Res. Section Abstract Doc Link 2147914 Disease Relevance 0.16 Pain Relevance 0.29
Six women without hypertension or proteinuria, admitted for severe upper abdominal pain in the third trimester of pregnancy had elevated serum liver enzymes (SGOT, SGPT), markedly increased serum LDH levels, thrombocytopenia and abnormal blood coagulation tests, in particular low antithrombin III levels, indicating disseminated intravascular coagulation (DIC).
Positive_regulation (increased) of antithrombin III in blood associated with abdominal pain, proteinuria, hypertension, disseminated intravascular coagulation and thrombocytopenia
8) Confidence 0.08 Published 1986 Journal Br J Obstet Gynaecol Section Abstract Doc Link 3511956 Disease Relevance 0.96 Pain Relevance 0.10
Estimation of antithrombin III, alpha 2 macroglobulin and alpha 1 antitrypsin in patients with stable and unstable angina and acute myocardial infarction (15 cases each) were carried out.
Positive_regulation (Estimation) of antithrombin III associated with angina and myocardial infarction
9) Confidence 0.06 Published 1990 Journal Indian Heart J Section Abstract Doc Link 1711506 Disease Relevance 0.61 Pain Relevance 0.17
Activated protein C and antithrombin III are most important inhibitors in plasma.
Positive_regulation (Activated) of antithrombin III in plasma
10) Confidence 0.05 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628130 Disease Relevance 1.04 Pain Relevance 0
Activated protein C and antithrombin III were measured in all hematomas.
Positive_regulation (Activated) of antithrombin III associated with hematoma
11) Confidence 0.05 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628130 Disease Relevance 1.12 Pain Relevance 0
The changes and our interpretation of them include the following: 1) the elevation of thrombin antithrombin III complex levels (activation of blood coagulation) was transient and monophasic; 2) the elevation of plasmin alpha 2-antiplasmin complex and D-dimer levels (activation of fibrinolysis) was biphasic, despite the monophasic elevation of tissue plasminogen activator or plasminogen activator inhibitor-1 levels; 3) the elevation of beta-thromboglobulin and platelet-factor-4 levels (activation of platelet) was also biphasic; 4) fibrinogen level and alpha 2-antiplasmin activity increased in the acute phase of the postoperative course (acute phase reaction); 5) the changes in hematocrit appeared to parallel those in various other parameters, especially platelet count, antithrombin III, and plasminogen levels for 1 or 2 days after surgery; 6) fibronectin appeared to be consumed in the acute phase of postoperative course; and 7) general anesthesia did not significantly affect hemostasis.
Positive_regulation (elevation) of antithrombin III in platelet associated with anesthesia and acute-phase reaction
12) Confidence 0.05 Published 1994 Journal Neurosurgery Section Abstract Doc Link 7936148 Disease Relevance 0.17 Pain Relevance 0.16
The patient had depressed antithrombin III activity and abnormally high concentrations of both fibrin degradation products and thrombin-antithrombin complexes.
Positive_regulation (concentrations) of antithrombin III
13) Confidence 0.04 Published 1998 Journal Clin. Rheumatol. Section Abstract Doc Link 9694066 Disease Relevance 0.75 Pain Relevance 0.34
The lower limits in measurement of activated protein C and antithrombin III were 10% and 25%, respectively.
Positive_regulation (activated) of antithrombin III
14) Confidence 0.04 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628130 Disease Relevance 1.11 Pain Relevance 0
Activated protein C and antithrombin III levels were decreased.
Positive_regulation (Activated) of antithrombin III
15) Confidence 0.04 Published 2007 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2628130 Disease Relevance 0.87 Pain Relevance 0
Platelets obtained during a headache-free period showed excessive responsiveness to collagen in vitro, while episodic elevations of thromboxane B(2) and thrombin-antithrombin III complex were noted in blood sampled during headache.
Positive_regulation (elevations) of thrombin-antithrombin III in blood associated with headache
16) Confidence 0.04 Published 2006 Journal Brain Dev. Section Abstract Doc Link 16168600 Disease Relevance 1.34 Pain Relevance 0.62
Thrombin/antithrombin III-complex plasma concentrations increased significantly during cardiopulmonary bypass, however, without showing differences between children with (225 +/- 49 micrograms/L) and without (149 +/- 31 micrograms/L) aprotinin treatment.
Positive_regulation (increased) of antithrombin III in plasma
17) Confidence 0.03 Published 1994 Journal J. Thorac. Cardiovasc. Surg. Section Abstract Doc Link 7513776 Disease Relevance 0.08 Pain Relevance 0.13
Serum protein, albumin, fibrinogen, antithrombin III, alpha 1-fetoprotein concentrations, serum activities of cholinesterase and glutamate dehydrogenase, activated partial thromboplastin time and prothrombin time were normal in all patients.
Positive_regulation (activated) of antithrombin III associated with glutamate
18) Confidence 0.03 Published 1996 Journal Digestion Section Abstract Doc Link 8739089 Disease Relevance 0.78 Pain Relevance 0.13
Both sialylation and fucosylation increased as a function of cancer on several proteins including Hemopexin, Kininogen-1, Antithrombin-III, and Haptoglobin-related protein, whereas decreased sialylation was detected on plasma protease C1 inhibitor.
Positive_regulation (increased) of Antithrombin-III in plasma associated with cancer
19) Confidence 0.02 Published 2007 Journal J. Proteome Res. Section Abstract Doc Link 17428079 Disease Relevance 1.17 Pain Relevance 0.43
Moreover, an excessive elevation of plasmin-antiplasmin complexes (9,200 ng/ml; normal range: 10-150), an elevated D-dimer, and an increase in thrombin-antithrombin III complexes were found.
Positive_regulation (increase) of thrombin-antithrombin III
20) Confidence 0.01 Published 1999 Journal Am. J. Hematol. Section Abstract Doc Link 10331514 Disease Relevance 0.84 Pain Relevance 0.06

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