INT14961

Context Info Confidence 0.30 First Reported 1989 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 3.42 Pain Relevance 1.70

extracellular space (Pf4) extracellular region (Pf4) protein complex assembly (Pf4) molecular_function (Pf4) protein complex (Pf4)

Anatomy Link Frequency platelet 6 plasma 2 Pf4 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Angina 19 99.28 Inflammation 11 95.76 cva 1 51.60 ischemia 4 41.04 imagery 6 5.00 Versed 3 5.00 cytokine 2 5.00 chemokine 2 5.00 anesthesia 1 5.00 Inflammatory response 1 5.00

Disease Link Frequency Relevance Heat Myocardial Infarction 35 99.84 Angina 11 99.28 Cv General 3 Under Development 9 97.52 INFLAMMATION 12 95.76 Apoptosis 22 82.08 Coronary Artery Disease 5 75.00 Thrombosis 2 75.00 Cv Unclassified Under Development 3 41.04 Infarction 7 35.52 Cicatrix 3 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Mean platelet factor 4(PF4) levels measured in 10 cases of each subgroup were significantly elevated in myocardial infarction (MI) (48.4 +/- 15.16 ng/ml) and III unstable angina patients (44.7 +/- 15.9 ng/ml) as compared to controls (25.42 +/- 12.47 ng/ml; P less than 0.01).

Positive_regulation (elevated) of Gene_expression (levels) of platelet factor 4 in platelet associated with angina and myocardial infarction

1) Confidence 0.30 Published 1990 Journal Indian Heart J Section Abstract Doc Link 1711506 Disease Relevance 0.92 Pain Relevance 0.34

Mean platelet factor 4(PF4) levels measured in 10 cases of each subgroup were significantly elevated in myocardial infarction (MI) (48.4 +/- 15.16 ng/ml) and III unstable angina patients (44.7 +/- 15.9 ng/ml) as compared to controls (25.42 +/- 12.47 ng/ml; P less than 0.01).

Positive_regulation (elevated) of Gene_expression (levels) of PF4 in platelet associated with angina and myocardial infarction

2) Confidence 0.30 Published 1990 Journal Indian Heart J Section Abstract Doc Link 1711506 Disease Relevance 0.91 Pain Relevance 0.33

On the other hand, the plasma levels of BTG and PF4 were increased in patients with variant angina as compared with those with stable exertional angina but did not show a significant circadian variation in both groups.

Positive_regulation (increased) of Gene_expression (levels) of PF4 in plasma associated with angina

3) Confidence 0.27 Published 1989 Journal Circulation Section Abstract Doc Link 2532074 Disease Relevance 0.84 Pain Relevance 0.87

This proinflammatory effect was combined with an enhanced expression of proangiogenic Platelet factor 4.

Positive_regulation (enhanced) of Gene_expression (expression) of Platelet factor 4 in Platelet

4) Confidence 0.10 Published 2010 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2954875 Disease Relevance 0.75 Pain Relevance 0.16

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