INT149614

Context Info Confidence 0.81 First Reported 2005 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 13 Total Number 13 Disease Relevance 6.12 Pain Relevance 3.65

peptidase activity (MMP13) extracellular space (MMP13) extracellular region (MMP13) Golgi apparatus (MMP13) proteinaceous extracellular matrix (MMP13) lysosome (MMP13)

Anatomy Link Frequency stroma 2 temporomandibular joint 2 chondrocyte 1 brain 1 osteoclasts 1 MMP13 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 194 100.00 Snapping jaw 14 99.60 cytokine 28 99.46 Inflammation 35 99.26 Osteoarthritis 214 99.08 cva 1 92.24 Pain 42 85.16 cINOD 11 73.36 ischemia 1 66.00 Pain score 12 62.80

Disease Link Frequency Relevance Heat Temporomandibular Joint Syndrome 14 99.60 INFLAMMATION 40 99.26 Osteoarthritis 226 99.08 Disease 27 96.32 Stroke 6 96.32 Hypercalcemia 12 93.56 Stress 12 93.44 Cancer 104 93.16 Pressure And Volume Under Development 2 92.80 Hemorrhage 2 92.24

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

MMP-13 (collagenase 3) localization in human temporomandibular joint discs with internal derangement.

Localization (localization) of MMP-13 in temporomandibular joint associated with snapping jaw

1) Confidence 0.81 Published 2008 Journal Acta Histochem. Section Title Doc Link 18262231 Disease Relevance 0.58 Pain Relevance 0.55

MMP-13 (collagenase 3) localization in human temporomandibular joint discs with internal derangement.

Localization (localization) of collagenase 3 in temporomandibular joint associated with snapping jaw

2) Confidence 0.78 Published 2008 Journal Acta Histochem. Section Title Doc Link 18262231 Disease Relevance 0.58 Pain Relevance 0.55

Gene expression of collagen type-II, collagen type-I, aggrecan, MMP-13, IL-6, Il-1?

Localization (aggrecan) of MMP-13

3) Confidence 0.65 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2921357 Disease Relevance 0.11 Pain Relevance 0

The study revealed that the most highly expressed MMPs are located in the stroma, except MMP13, which was located in the epithelium.

Neg (except) Localization (located) of MMP13 in stroma associated with metalloproteinase

4) Confidence 0.55 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.87 Pain Relevance 0.21

The study revealed that the most highly expressed MMPs are located in the stroma, except MMP13, which was located in the epithelium.

Localization (located) of MMP13 in stroma associated with metalloproteinase

5) Confidence 0.55 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.86 Pain Relevance 0.21

Consistent with quantitative real-time PCR findings, the ELISA assay demonstrated that levels of MMP-1 and MMP-13 protein secreted into the media were significantly decreased by 10 mmol/l glucosamine (P < 0.05; Figure 1c,d).

Localization (secreted) of MMP-13

6) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212570 Disease Relevance 0 Pain Relevance 0.03

Results show that ET-1 greatly increased MMP-1 and MMP-13 production, iNOS expression and NO release.

Localization (release) of MMP-13

7) Confidence 0.40 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1065327 Disease Relevance 0.31 Pain Relevance 0.07

Among all the MMPs, we have recently demonstrated an induction in the synthesis, secretion and activation of two collagenases (MMP-1 and MMP-13) by ET-1 [2].

Localization (secretion) of MMP-13

8) Confidence 0.40 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.47 Pain Relevance 0.19

Although the exact cellular source of MMPs remains unknown, brain endothelium, astrocytes, neurons, and inflammatory-activated cells, such as neutrophils, may release MMP-2, MMP-3, MMP-8, MMP-9, MMP-10, and/or MMP-13.

Localization (release) of MMP-13 in brain associated with inflammation and metalloproteinase

9) Confidence 0.38 Published 2010 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 20955435 Disease Relevance 1.09 Pain Relevance 0.53

Under the influence of pro-inflammatory cytokines, increased production and secretion of collagenases such as MMP-3, MMP-13 is the crucial event for enhanced collagen degradation in OA 39.

Localization (secretion) of MMP-13 associated with inflammation, osteoarthritis and cytokine

10) Confidence 0.37 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2974165 Disease Relevance 0.75 Pain Relevance 0.56

Tardif and colleagues [32] have described two OA chondrocyte populations distinctive by their MMP-13 content and their response to IL-1?.

Localization (response) of MMP-13 in chondrocyte associated with osteoarthritis

11) Confidence 0.37 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.23 Pain Relevance 0.16

The role of MMP-13 in bone biology is of major importance as, on the one hand, MMP-13 secretion from the osteoblasts could be responsible for increasing type I collagen degradation and, on the other hand, in osteoclasts it could contribute to an increased bone resorption process.

Localization (secretion) of MMP-13 in osteoclasts associated with hypercalcemia

12) Confidence 0.27 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483463 Disease Relevance 0.27 Pain Relevance 0.11

The pro and active gelatinases (MMP-2 and MMP-9), collagenases (MMP-1 and MMP-13), and stromelysins (MMP-3 and MMP-10) levels released in the media were measured using a Quantikine colorimetric and Fluorokine fluorometric enzyme immunoassay (EIA) kit (R&D Systems Minneapolis, MN) using the manufacturer's instructions.

Localization (released) of MMP-13 associated with metalloproteinase

13) Confidence 0.09 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1559713 Disease Relevance 0 Pain Relevance 0.47

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