INT14962

Context Info Confidence 0.76 First Reported 1984 Last Reported 2010 Negated 0 Speculated 2 Reported most in Abstract Documents 27 Total Number 31 Disease Relevance 22.48 Pain Relevance 10.88

extracellular space (Pf4) extracellular region (Pf4) protein complex assembly (Pf4) molecular_function (Pf4) protein complex (Pf4)

Anatomy Link Frequency platelet 14 plasma 12 blood 1 monocytes 1 endothelial cell 1 Pf4 (Rattus norvegicus)

Pain Link Frequency Relevance Heat chemokine 6 99.92 ischemia 34 99.68 depression 18 99.54 aspirin 26 99.24 Angina 86 98.68 Inflammation 36 97.48 cOX1 1 97.40 Migraine 21 95.68 tolerance 4 91.04 headache 4 90.56

Disease Link Frequency Relevance Heat Coronary Artery Disease 25 99.72 Cv Unclassified Under Development 26 99.68 Depression 18 99.54 Acute Coronary Syndrome 25 99.24 Sickle Cell Anemia 15 98.72 Angina 51 98.68 Adhesions 8 97.84 INFLAMMATION 39 97.48 Myocardial Infarction 102 97.20 Muscular Spasm 5 96.60

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The plasma levels of beta-thromboglobulin (beta-TG) and platelet factor 4 (PF4), indices of the occurrence of platelet activation in vivo, were therefore first assayed in both groups of migraine sufferers in the absence of therapy and then during the administration of aspirin (50 mg/daily).

Gene_expression (levels) of PF4 in plasma associated with aspirin and migraine

1) Confidence 0.76 Published 1984 Journal Stroke Section Abstract Doc Link 6230778 Disease Relevance 0.69 Pain Relevance 0.82

The plasma levels of beta-thromboglobulin (beta-TG) and platelet factor 4 (PF4), indices of the occurrence of platelet activation in vivo, were therefore first assayed in both groups of migraine sufferers in the absence of therapy and then during the administration of aspirin (50 mg/daily).

Gene_expression (levels) of platelet factor 4 in plasma associated with aspirin and migraine

2) Confidence 0.67 Published 1984 Journal Stroke Section Abstract Doc Link 6230778 Disease Relevance 0.69 Pain Relevance 0.77

Simultaneously, the plasma levels of platelet factor 4 (PF4) and of beta-thromboglobulin (beta-TG) were measured.

Gene_expression (levels) of platelet factor 4 in platelet

3) Confidence 0.58 Published 1984 Journal Thromb. Haemost. Section Abstract Doc Link 6241754 Disease Relevance 0.51 Pain Relevance 0.11

Simultaneously, the plasma levels of platelet factor 4 (PF4) and of beta-thromboglobulin (beta-TG) were measured.

Gene_expression (levels) of PF4 in platelet

4) Confidence 0.58 Published 1984 Journal Thromb. Haemost. Section Abstract Doc Link 6241754 Disease Relevance 0.51 Pain Relevance 0.11

Simultaneous arterial and great cardiac vein samples were drawn during control and ischemia to measure the levels of platelet factor four (PF4) and beta-thromboglobulin (BTG).

Gene_expression (levels) of PF4 in platelet associated with ischemia

5) Confidence 0.55 Published 1986 Journal Am. Heart J. Section Abstract Doc Link 2943147 Disease Relevance 0.61 Pain Relevance 0.31

Simultaneous arterial and great cardiac vein samples were drawn during control and ischemia to measure the levels of platelet factor four (PF4) and beta-thromboglobulin (BTG).

Gene_expression (levels) of platelet factor in platelet associated with ischemia

6) Confidence 0.55 Published 1986 Journal Am. Heart J. Section Abstract Doc Link 2943147 Disease Relevance 0.60 Pain Relevance 0.31

There were no signs of increased platelet activity at rest or after exercise as judged by the levels of BTG and PF4.

Gene_expression (levels) of PF4 in platelet

7) Confidence 0.44 Published 1987 Journal Eur. Heart J. Section Abstract Doc Link 2949974 Disease Relevance 0.23 Pain Relevance 0.39

Plasma levels of fibrinopeptide A (FPA), beta-thromboglobulin (BTG), and platelet factor 4 (PF4) were examined on venous plasma samples taken every 4 hours for 24 hours in 20 patients with variant angina and 20 patients with stable exertional angina together with 24-hour Holter recordings.

Spec (examined) Gene_expression (levels) of PF4 in plasma associated with angina

8) Confidence 0.40 Published 1989 Journal Circulation Section Abstract Doc Link 2532074 Disease Relevance 0.45 Pain Relevance 0.45

Plasma levels of fibrinopeptide A (FPA), beta-thromboglobulin (BTG), and platelet factor 4 (PF4) were examined on venous plasma samples taken every 4 hours for 24 hours in 20 patients with variant angina and 20 patients with stable exertional angina together with 24-hour Holter recordings.

Spec (examined) Gene_expression (levels) of platelet factor 4 in plasma associated with angina

9) Confidence 0.40 Published 1989 Journal Circulation Section Abstract Doc Link 2532074 Disease Relevance 0.45 Pain Relevance 0.45

Mean platelet factor 4(PF4) levels measured in 10 cases of each subgroup were significantly elevated in myocardial infarction (MI) (48.4 +/- 15.16 ng/ml) and III unstable angina patients (44.7 +/- 15.9 ng/ml) as compared to controls (25.42 +/- 12.47 ng/ml; P less than 0.01).

Gene_expression (levels) of PF4 in platelet associated with angina and myocardial infarction

10) Confidence 0.40 Published 1990 Journal Indian Heart J Section Abstract Doc Link 1711506 Disease Relevance 0.89 Pain Relevance 0.32

Mean platelet factor 4(PF4) levels measured in 10 cases of each subgroup were significantly elevated in myocardial infarction (MI) (48.4 +/- 15.16 ng/ml) and III unstable angina patients (44.7 +/- 15.9 ng/ml) as compared to controls (25.42 +/- 12.47 ng/ml; P less than 0.01).

Gene_expression (levels) of platelet factor 4 in platelet associated with angina and myocardial infarction

11) Confidence 0.40 Published 1990 Journal Indian Heart J Section Abstract Doc Link 1711506 Disease Relevance 0.89 Pain Relevance 0.32

Inhibition of platelet cyclooxygenase (COX 1) by aspirin is followed by relief of microvascular disturbances, correction of shortened platelet survival, and return of plasma levels of beta-tg, PF4, TM levels and TxB2 excretion to normal.

Gene_expression (levels) of PF4 in plasma associated with aspirin and cox1

12) Confidence 0.39 Published 2006 Journal Platelets Section Abstract Doc Link 17127481 Disease Relevance 1.35 Pain Relevance 0.21

On the other hand, the plasma levels of BTG and PF4 were increased in patients with variant angina as compared with those with stable exertional angina but did not show a significant circadian variation in both groups.

Gene_expression (levels) of PF4 in plasma associated with angina

13) Confidence 0.35 Published 1989 Journal Circulation Section Abstract Doc Link 2532074 Disease Relevance 0.84 Pain Relevance 0.86

We conclude that 1) plasma levels of FPA, BTG, and PF4 were increased in patients with variant angina as compared with those with stable exertional angina; 2) there was a significant circadian variation in the plasma levels of FPA in parallel with that of the frequency of the attacks with the peak level occurring from midnight to early morning in patients with variant angina; and 3) elevated levels of plasma FPA are the result and not the cause of coronary spasm.

Gene_expression (levels) of PF4 in plasma associated with angina and cva

14) Confidence 0.35 Published 1989 Journal Circulation Section Abstract Doc Link 2532074 Disease Relevance 0.94 Pain Relevance 0.90

Plasma FPA and PF 4 levels in group 1 were also significantly higher than those in normal subjects and group 2.

Gene_expression (levels) of PF 4 in Plasma

15) Confidence 0.35 Published 1996 Journal Jpn. Circ. J. Section Abstract Doc Link 8803721 Disease Relevance 1.31 Pain Relevance 0.77

Plasma levels of the alpha-granule constituents beta-thromboglobulin and platelet factor 4 were measured in patients with sickle cell anemia during steady state and vaso-occlusive crisis in order to determine in vivo platelet activity.

Gene_expression (levels) of platelet factor 4 in Plasma associated with sickle cell anemia

16) Confidence 0.29 Published 1993 Journal Acta Haematol. Section Abstract Doc Link 8212998 Disease Relevance 0.44 Pain Relevance 0.07

The platelet release proteins, beta-thromboglobulin (BTG) and platelet factor 4 (PF4), were markedly elevated in the first 2 days and dropped gradually thereafter.

Gene_expression (dropped) of platelet factor 4 in platelet

17) Confidence 0.24 Published 1994 Journal Int. J. Cardiol. Section Abstract Doc Link 8181885 Disease Relevance 0.43 Pain Relevance 0.35

Aspirin treatment of erythromelalgia in thrombocythemia patients resulted in the disappearance of the erythromelalgic, thrombotic signs and symptoms, correction of the shortened platelet survival times, and a significant reduction of the increased levels of beta-TG, PF4, TM and urinary TxB2 excretion to normal.

Gene_expression (levels) of PF4 in platelet associated with aspirin, thrombocytosis and erythermalgia

18) Confidence 0.17 Published 2003 Journal Pathol. Biol. Section Abstract Doc Link 12781799 Disease Relevance 1.41 Pain Relevance 0.30

As compared with control subjects, asymptomatic subjects with SCD demonstrated significantly increased platelet activation (P <.01 for P-selectin and annexin V binding), elevated plasma levels of PF4 and betaTG (P <.01 and P <.03, respectively), and increased plasma concentrations of F(1.2), TAT, PAP, and D -dimer (P <.05 in all cases).

Gene_expression (levels) of PF4 in plasma associated with sickle cell anemia

19) Confidence 0.17 Published 2001 Journal J. Lab. Clin. Med. Section Abstract Doc Link 11385360 Disease Relevance 0.78 Pain Relevance 0.35

Arterial blood gases, pulmonary function, mean pulmonary arterial pressure, left ventricular ejection fraction (LVEF), right ventricular ejection fraction (RVEF), white blood cell count, C-reactive protein and the plasma concentrations of fibrinopeptide A, beta-thromboglobulin, platelet factor 4 and thrombomodulin were evaluated before and 2 and 12 months after SH administration.

Gene_expression (evaluated) of platelet factor 4 in white blood cell

20) Confidence 0.12 Published 2000 Journal J. Int. Med. Res. Section Abstract Doc Link 11191719 Disease Relevance 0.65 Pain Relevance 0.08

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