INT149622

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.48
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs2) oxidoreductase activity (Ptgs2) endoplasmic reticulum (Ptgs2)
nucleus (Ptgs2) enzyme binding (Ptgs2) protein complex (Ptgs2)
Ptgs2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 20 100.00 Very High Very High Very High
Thermal hyperalgesia 2 99.64 Very High Very High Very High
COX2 3 98.84 Very High Very High Very High
Antinociceptive 2 95.48 Very High Very High Very High
cytokine 3 94.32 High High
Inflammatory mediators 2 89.60 High High
Spinal cord 3 88.56 High High
IPN 5 86.16 High High
Lasting pain 2 73.60 Quite High
Pain 3 71.32 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 18 100.00 Very High Very High Very High
Necrosis 4 100.00 Very High Very High Very High
Cancer 4 100.00 Very High Very High Very High
Hyperalgesia 3 99.64 Very High Very High Very High
Encephalitis 1 93.76 High High
Inflammatory Pain 5 86.16 High High
Nociception 27 74.96 Quite High
Pain 4 73.60 Quite High
Targeted Disruption 9 55.00 Quite High
Hypersensitivity 1 46.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Role of interleukin-1beta and tumor necrosis factor-alpha-dependent expression of cyclooxygenase-2 mRNA in thermal hyperalgesia induced by chronic inflammation in mice.
Positive_regulation (dependent) of Transcription (expression) of cyclooxygenase-2 associated with necrosis, inflammation, cancer, thermal hyperalgesia and cox2
1) Confidence 0.28 Published 2008 Journal Neuroscience Section Title Doc Link 18262365 Disease Relevance 0.84 Pain Relevance 0.83
ME10092 dose-dependently inhibited LPS-induced nuclear translocation of NF-kappaB, transcription of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
Positive_regulation (induced) of Transcription (transcription) of cyclooxygenase-2 associated with necrosis and cancer
2) Confidence 0.18 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20074673 Disease Relevance 0.53 Pain Relevance 0.25
For example, 15d-PGJ2 represses the transcription of a number of pro-inflammatory factors including inducible nitric oxide synthase, cyclooxygenase-2 and tumor necrosis factor-?
Positive_regulation (inducible) of Transcription (transcription) of cyclooxygenase-2 associated with necrosis, inflammation and cancer
3) Confidence 0.10 Published 2008 Journal Mol Pain Section Body Doc Link PMC2515828 Disease Relevance 1.11 Pain Relevance 0.38

General Comments

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