INT149623

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Context Info
Confidence 0.12
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 10.56
Pain Relevance 4.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
hinge 1
dendritic cells 1
fc (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 5 99.92 Very High Very High Very High
Arthritis 209 99.62 Very High Very High Very High
IPN 3 99.12 Very High Very High Very High
abatacept 5 98.76 Very High Very High Very High
rheumatoid arthritis 422 97.28 Very High Very High Very High
Thermal hyperalgesia 2 95.36 Very High Very High Very High
Inflammation 151 94.32 High High
psoriasis 1 93.64 High High
cytokine 43 91.60 High High
Spinal cord 3 85.24 High High
Disease Link Frequency Relevance Heat
Sprains And Strains 27 99.86 Very High Very High Very High
Arthritis 216 99.62 Very High Very High Very High
Inflammatory Pain 3 99.12 Very High Very High Very High
Arthus Reaction 32 99.04 Very High Very High Very High
Hypersensitivity 12 98.70 Very High Very High Very High
Rheumatoid Arthritis 423 97.28 Very High Very High Very High
Systemic Lupus Erythematosus 76 97.28 Very High Very High Very High
Syndrome 12 96.40 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 95.92 Very High Very High Very High
Autoimmune Disease 88 95.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased activity of PBGD, in connection with decreased FC activity in neoplastic tissue, have been reported to be possible factors behind the selective accumulation of PpIX (Dailey and Smith 1984; Leibovici et al 1988; Kondo et al 1993; Hinnen et al 1998; Gibson et al 1998).
Negative_regulation (decreased) of FC
1) Confidence 0.12 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503644 Disease Relevance 0.24 Pain Relevance 0
RIII) were not susceptible to arthritis induction after an injection of collagen or adjuvant [35]; in addition, a lack of the inhibitory receptor Fc?
Negative_regulation (lack) of Fc associated with arthritis
2) Confidence 0.11 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.52 Pain Relevance 0.41
RII is downregulated and these cells subsequently lack the ability to downregulate Fc?
Negative_regulation (downregulate) of Fc
3) Confidence 0.11 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 0.61 Pain Relevance 0.12
chain [43], and arthritis was significantly suppressed in Fc?
Negative_regulation (suppressed) of Fc associated with arthritis
4) Confidence 0.11 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.51 Pain Relevance 0.51
RII- /- mice showed an enhanced Arthus reaction owing to the absence of its modulatory role in inhibiting Fc?
Negative_regulation (inhibiting) of Fc associated with arthus reaction
5) Confidence 0.11 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.09 Pain Relevance 0.19
This decrease of Fc?
Negative_regulation (decrease) of Fc
6) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888223 Disease Relevance 0.62 Pain Relevance 0.27
The effect of TNF blockage, however, was not sufficient to prevent the downregulation of Fc?
Negative_regulation (downregulation) of Fc
7) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888223 Disease Relevance 0.26 Pain Relevance 0.16
Reduced Fc?
Negative_regulation (Reduced) of Fc
8) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888223 Disease Relevance 0.79 Pain Relevance 0.31
RIIa but reducing Fc?
Negative_regulation (reducing) of Fc
9) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888223 Disease Relevance 0.26 Pain Relevance 0.21
Moreover, depending on the strain, mice deficient in Fc?
Negative_regulation (deficient) of Fc associated with sprains and strains
10) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888223 Disease Relevance 1.22 Pain Relevance 0.26
RIIb, since studies on dendritic cells (DCs) have demonstrated that exposure to immune complexes together with a blockage of Fc?
Negative_regulation (blockage) of Fc in dendritic cells
11) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888223 Disease Relevance 0.80 Pain Relevance 0.25
RI antibody actually inhibited Fc?
Negative_regulation (inhibited) of Fc
12) Confidence 0.03 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987830 Disease Relevance 0 Pain Relevance 0
Alteration of signal transduction pathways to impair Fc?
Negative_regulation (impair) of Fc
13) Confidence 0.02 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987830 Disease Relevance 0.10 Pain Relevance 0
Furthermore, CFA-induced hypersensitivity to inflammatory pain was significantly reduced by repeated i.t. pre-injection of the recombinant Fc chimera of IL-1 receptor I or soluble TNF receptor I, which sequesters endogenous IL-1beta or TNF-alpha, respectively.
Negative_regulation (pre-injection) of Fc chimera associated with ipn and hypersensitivity
14) Confidence 0.02 Published 2008 Journal Neuroscience Section Abstract Doc Link 18262365 Disease Relevance 0.96 Pain Relevance 0.85
Thus, in abatacept, a series of directed cysteine to serine mutations were introduced in the hinge region to reduce this Fc- mediated binding.21 Although abatacept proved to be highly efficacious for autoimmune T cell-mediated autoimmune disorders, such as rheumatoid arthritis and psoriasis, it was found to be an inadequate maintenance immunosuppressive agent in nonhuman primate models of transplantation.22–24 Studies into potential reasons for this disconnect found that although CTLA4 binds with a much higher avidity to CD80 and CD86 than does CD28, CTLA4-Ig was significantly less potent at inhibiting CD86-dependent as opposed to CD80-dependent costimulation.25
Negative_regulation (reduce) of Fc in hinge associated with psoriasis, autoimmune disease, rheumatoid arthritis and abatacept
15) Confidence 0.01 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998809 Disease Relevance 0.34 Pain Relevance 0.42
A preparation of IgG Fc that lacked IgG4 Fc was resolved on 10 % SDS-PAGE and blotted.
Negative_regulation (lacked) of Fc
16) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.23 Pain Relevance 0
NE depletion in the mpFC
Negative_regulation (depletion) of mpFC
17) Confidence 0.00 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516177 Disease Relevance 0 Pain Relevance 0.10

General Comments

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