INT149642
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Increased cytoplasmic localization of ELAVL1 protein is associated with increased oxidative stress and enhanced MAPKAPK2/3 phosphorylation (Lal et al., 2004; Raineri et al., 2004; Cherry et al., 2006). | |||||||||||||||
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We are testing a model that predicts that ZFP36 and KHSRP may therefore oppose ELAVL1 binding and that p38 MAPK ? | |||||||||||||||
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The array of HuR target mRNAs is large, as analyzed by profiling of mRNAs that are bound to HuR protein which include many cytokines, growth factors, cell-cycle regulators, and many others [43, 80, 82]. | |||||||||||||||
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The RNA motif NNUUNNUUU for HuR binding is also functional as linear conformation or as a linear segment within a secondary structure; the latter conformation promotes further recognition by the RNA-binding protein [4043]. | |||||||||||||||
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Stability of iNOS mRNA is regulated by RNA stabilizing factor, e.g., Hu antigen R (HuR), and RNA destabilizing factors, e.g., AU-rich element/poly(U) binding factor-1 (AUF-1) and tristetraprolin (TTP). | |||||||||||||||
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Stability of iNOS mRNA is regulated by RNA stabilizing factor, e.g., Hu antigen R (HuR), and RNA destabilizing factors, e.g., AU-rich element/poly(U) binding factor-1 (AUF-1) and tristetraprolin (TTP). | |||||||||||||||
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Overexpression and cytoplasmic localization of stabilizing ARE binding proteins, notably HuR, with commitment functional loss of RNA decay-promoting proteins such as TTP can be associated with chronic inflammation and cancer. | |||||||||||||||
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Overexpression and cytoplasmic localization of stabilizing ARE binding proteins, notably HuR, with commitment functional loss of RNA decay-promoting proteins such as TTP can be associated with chronic inflammation and cancer. | |||||||||||||||
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The VEGF mRNA is a target for HuR binding and effect. | |||||||||||||||
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Associations of KSRP and AUF1 p45, or KSRP and HuR, allow fine tuning of ARE-mRNA stability [93, 94]. | |||||||||||||||
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General Comments
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