INT149642

Context Info Confidence 0.23 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 10 Disease Relevance 5.49 Pain Relevance 1.59

RNA binding (Elavl1) nucleus (Elavl1) cytoplasm (Elavl1)

Anatomy Link Frequency poly 2 Elavl1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 698 99.44 cytokine 202 98.88 Inflammatory stimuli 18 93.68 Clonidine 6 92.16 Pain management 2 85.32 anesthesia 2 84.16 Inflammatory response 26 80.04 Arthritis 32 61.44 Kinase C 26 21.52 chemokine 60 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 726 99.44 Stress 24 98.96 Cancer 866 98.76 Congenital Anomalies 18 95.80 Colon Cancer 48 91.28 Lung Cancer 12 87.48 Metastasis 54 86.28 Pain 2 84.88 Sleep Disorders 2 84.52 Hypertension 2 82.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Increased cytoplasmic localization of ELAVL1 protein is associated with increased oxidative stress and enhanced MAPKAPK2/3 phosphorylation (Lal et al., 2004; Raineri et al., 2004; Cherry et al., 2006).

ELAVL1 protein Binding (associated) of associated with stress

1) Confidence 0.23 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639449 Disease Relevance 0.16 Pain Relevance 0.03

We are testing a model that predicts that ZFP36 and KHSRP may therefore oppose ELAVL1 binding and that p38 MAPK ?

ELAVL1 Binding (binding) of

2) Confidence 0.23 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639449 Disease Relevance 0.11 Pain Relevance 0.03

The array of HuR target mRNAs is large, as analyzed by profiling of mRNAs that are bound to HuR protein which include many cytokines, growth factors, cell-cycle regulators, and many others [43, 80, 82].

HuR Binding (bound) of associated with cytokine

3) Confidence 0.22 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.24 Pain Relevance 0.11

The RNA motif NNUUNNUUU for HuR binding is also functional as linear conformation or as a linear segment within a secondary structure; the latter conformation promotes further recognition by the RNA-binding protein [40–43].

HuR Binding (binding) of

4) Confidence 0.22 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0 Pain Relevance 0

Stability of iNOS mRNA is regulated by RNA stabilizing factor, e.g., Hu antigen R (HuR), and RNA destabilizing factors, e.g., AU-rich element/poly(U) binding factor-1 (AUF-1) and tristetraprolin (TTP).

HuR Binding (binding) of in poly

5) Confidence 0.21 Published 2008 Journal J. Surg. Res. Section Abstract Doc Link 18262561 Disease Relevance 0.41 Pain Relevance 0.46

Stability of iNOS mRNA is regulated by RNA stabilizing factor, e.g., Hu antigen R (HuR), and RNA destabilizing factors, e.g., AU-rich element/poly(U) binding factor-1 (AUF-1) and tristetraprolin (TTP).

antigen R Binding (binding) of in poly

6) Confidence 0.19 Published 2008 Journal J. Surg. Res. Section Abstract Doc Link 18262561 Disease Relevance 0.41 Pain Relevance 0.46

Overexpression and cytoplasmic localization of stabilizing ARE binding proteins, notably HuR, with commitment functional loss of RNA decay-promoting proteins such as TTP can be associated with chronic inflammation and cancer.

HuR Binding (binding) of associated with inflammation and cancer

7) Confidence 0.17 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.22 Pain Relevance 0.17

Overexpression and cytoplasmic localization of stabilizing ARE binding proteins, notably HuR, with commitment functional loss of RNA decay-promoting proteins such as TTP can be associated with chronic inflammation and cancer.

HuR Binding (associated) of associated with inflammation and cancer

8) Confidence 0.17 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.31 Pain Relevance 0.21

The VEGF mRNA is a target for HuR binding and effect.

HuR Binding (binding) of

9) Confidence 0.17 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.26 Pain Relevance 0

Associations of KSRP and AUF1 p45, or KSRP and HuR, allow fine tuning of ARE-mRNA stability [93, 94].

HuR Binding (Associations) of

10) Confidence 0.17 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.36 Pain Relevance 0.14

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