INT149643

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.45
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Zfp36) mRNA binding (Zfp36) nucleus (Zfp36)
DNA binding (Zfp36) response to stress (Zfp36) cytoplasm (Zfp36)
Anatomy Link Frequency
poly 1
Zfp36 (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 3 95.52 Very High Very High Very High
cytokine 33 85.64 High High
Pain management 1 82.20 Quite High
anesthesia 1 81.04 Quite High
Inflammatory response 5 76.92 Quite High
Inflammation 116 50.00 Quite Low
Inflammatory stimuli 3 39.76 Quite Low
chemokine 10 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 1 81.76 Quite High
Sleep Disorders 1 81.40 Quite High
Hypertension 1 79.24 Quite High
Sepsis 1 77.48 Quite High
INFLAMMATION 121 76.56 Quite High
Targeted Disruption 6 56.08 Quite High
Cancer 144 50.00 Quite Low
Disease 9 13.00 Low Low
Hypoxia 11 5.00 Very Low Very Low Very Low
Metastasis 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tristetraprolin and several other RNA-binding proteins such as BRF1, KSRP, and AUF1 appear to function by targeting AU-rich mRNA to the exosome, a multiprotein complex with 3?
Tristetraprolin Binding (complex) of
1) Confidence 0.29 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.06 Pain Relevance 0.04
Stability of iNOS mRNA is regulated by RNA stabilizing factor, e.g., Hu antigen R (HuR), and RNA destabilizing factors, e.g., AU-rich element/poly(U) binding factor-1 (AUF-1) and tristetraprolin (TTP).
TTP Binding (binding) of in poly
2) Confidence 0.11 Published 2008 Journal J. Surg. Res. Section Abstract Doc Link 18262561 Disease Relevance 0.40 Pain Relevance 0.45

General Comments

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