INT149644

Context Info Confidence 0.32 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 14 Disease Relevance 13.13 Pain Relevance 1.27

RNA binding (Elavl1) nucleus (Elavl1) cytoplasm (Elavl1)

Anatomy Link Frequency colon 2 lung 2 MDA-MB-231 2 Elavl1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 1508 99.48 cytokine 429 95.04 Inflammatory stimuli 39 84.32 Kinase C 52 69.36 Clonidine 3 50.00 Arthritis 65 28.56 chemokine 130 5.00 cINOD 65 5.00 Inflammatory response 53 5.00 aspirin 13 5.00

Disease Link Frequency Relevance Heat Cancer 1872 99.92 Ovarian Cancer 26 99.58 INFLAMMATION 1561 99.48 Lung Cancer 26 99.00 Breast Cancer 65 98.32 Congenital Anomalies 26 98.32 Glioblastoma 13 97.72 Hyperplasia 65 97.20 Disease 117 95.80 Colon Cancer 104 89.44

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Elevated HuR expression occurs with the loss of TTP expression at an early stage of colorectal tumorigenesis that is associated with increased COX-2 expression [71].

Positive_regulation (Elevated) of Gene_expression (expression) of HuR

1) Confidence 0.32 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.86 Pain Relevance 0.19

Cytoplasmic expression of HuR is increased in urethane-induced neoplasia and in butylated hydroxytoluene-induced compensatory hyperplasia in mouse lung tissue [152].

Positive_regulation (increased) of Gene_expression (expression) of HuR in lung associated with cancer and hyperplasia

2) Confidence 0.32 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.28 Pain Relevance 0

The highly invasive breast cancer cell line, MDA-MB-231, which has increased constitutive levels of uPA, is due to impairment in the ARE-mediated decay of uPA mRNA; this is correlated with HuR overexpression and p38 MAP kinase induction [113].

Positive_regulation (overexpression) of Gene_expression (overexpression) of HuR in MDA-MB-231 associated with breast cancer

3) Confidence 0.32 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.10 Pain Relevance 0.06

It is associated with increased HuR expression in different types of cancers; for example, major HuR expression is detected in perinecrotic areas in which VEGF, COX-2, and IL-8, all angiogenesis factors, are up-regulated [151].

Positive_regulation (increased) of Gene_expression (expression) of HuR associated with cancer

4) Confidence 0.32 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.20 Pain Relevance 0

Breast, colon, gastric, prostate, and ovarian cancers have been linked to overexpression of HuR and increased cytoplasmic localization, when compared to normal tissues [143, 147–150].

Positive_regulation (overexpression) of Gene_expression (overexpression) of HuR in colon associated with ovarian cancer

5) Confidence 0.32 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.06 Pain Relevance 0.03

Several studies have pointed out that HuR is overexpressed in tumor cells when compared to their normal counterparts, with increased localization of HuR in cytoplasmic compartments.

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of HuR associated with cancer

6) Confidence 0.32 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.85 Pain Relevance 0.03

The LPS-induced expression of AUF-1 and TTP but not HuR was significantly enhanced by clonidine.

Positive_regulation (enhanced) of Gene_expression (expression) of HuR

7) Confidence 0.29 Published 2008 Journal J. Surg. Res. Section Body Doc Link 18262561 Disease Relevance 0 Pain Relevance 0

CUGBP2 can override HuR and suppresses COX-2 mRNA translation [95].

Positive_regulation (override) of Gene_expression (override) of HuR

8) Confidence 0.23 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.52 Pain Relevance 0.20

Ectopic expression of HuR overcomes TTP-mediated destabilization of IL-3 mRNA and HuR mRNA in an ARE-dependent manner [69, 73].

Positive_regulation (overcomes) of Gene_expression (expression) of HuR

9) Confidence 0.23 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.39 Pain Relevance 0.16

HuR overexpression and cytoplasmic localization leads to binding to, and upregulation of, COX-2 mRNA expression in a number of cancers [71, 156–159].

Positive_regulation (overexpression) of Gene_expression (overexpression) of HuR associated with cancer

10) Confidence 0.23 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.30 Pain Relevance 0

Overexpression and cytoplasmic localization of stabilizing ARE binding proteins, notably HuR, with commitment functional loss of RNA decay-promoting proteins such as TTP can be associated with chronic inflammation and cancer.

Positive_regulation (Overexpression) of Gene_expression (Overexpression) of HuR associated with inflammation and cancer

11) Confidence 0.23 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.30 Pain Relevance 0.17

Overexpression of RNA-binding protein that tends to stabilize AU-rich mRNAs such as HuR and certain isoforms of AUF1 is observed in certain cancers.

Positive_regulation (Overexpression) of Gene_expression (Overexpression) of HuR associated with cancer

12) Confidence 0.23 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.13 Pain Relevance 0.22

Elevated HuR expression occurs with the loss of TTP expression at an early stage of colorectal tumorigenesis that is associated with increased COX-2 expression [71].

Positive_regulation (occurs) of Gene_expression (expression) of HuR

13) Confidence 0.21 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.81 Pain Relevance 0.19

However, certain studies have shown that HuR overexpression may be limited to a small sub-set of tumors [153].

Positive_regulation (overexpression) of Gene_expression (overexpression) of HuR associated with cancer

14) Confidence 0.21 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.34 Pain Relevance 0

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