INT149646

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 19
Disease Relevance 18.47
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Elavl1) nucleus (Elavl1) cytoplasm (Elavl1)
Anatomy Link Frequency
lymph node 1
colon 1
lung 1
MDA-MB-231 1
Elavl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 2088 99.48 Very High Very High Very High
cytokine 594 95.04 Very High Very High Very High
Kinase C 72 90.48 High High
Inflammatory stimuli 54 84.32 Quite High
Clonidine 3 50.00 Quite Low
Arthritis 90 28.56 Quite Low
chemokine 180 5.00 Very Low Very Low Very Low
cINOD 90 5.00 Very Low Very Low Very Low
Inflammatory response 73 5.00 Very Low Very Low Very Low
aspirin 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 2592 99.92 Very High Very High Very High
Ovarian Cancer 36 99.58 Very High Very High Very High
INFLAMMATION 2161 99.48 Very High Very High Very High
Lung Cancer 36 99.00 Very High Very High Very High
Breast Cancer 90 98.32 Very High Very High Very High
Congenital Anomalies 36 98.32 Very High Very High Very High
Hypoxia 198 98.24 Very High Very High Very High
Glioblastoma 18 97.72 Very High Very High Very High
Hyperplasia 90 97.20 Very High Very High Very High
Metastasis 162 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The LPS-induced expression of AUF-1 and TTP but not HuR was significantly enhanced by clonidine.
Gene_expression (expression) of HuR
1) Confidence 0.44 Published 2008 Journal J. Surg. Res. Section Body Doc Link 18262561 Disease Relevance 0 Pain Relevance 0
Further indirect evidence is that RNase L suppression of cellular growth is associated with reduction in HuR mRNA expression [146].
Gene_expression (expression) of HuR mRNA
2) Confidence 0.35 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.81 Pain Relevance 0.03
It is associated with increased HuR expression in different types of cancers; for example, major HuR expression is detected in perinecrotic areas in which VEGF, COX-2, and IL-8, all angiogenesis factors, are up-regulated [151].
Gene_expression (expression) of HuR associated with cancer
3) Confidence 0.35 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.19 Pain Relevance 0
Ectopic expression of HuR overcomes TTP-mediated destabilization of IL-3 mRNA and HuR mRNA in an ARE-dependent manner [69, 73].
Gene_expression (expression) of HuR
4) Confidence 0.35 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.39 Pain Relevance 0.16
However, certain studies have shown that HuR overexpression may be limited to a small sub-set of tumors [153].
Gene_expression (overexpression) of HuR associated with cancer
5) Confidence 0.35 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.34 Pain Relevance 0
Breast, colon, gastric, prostate, and ovarian cancers have been linked to overexpression of HuR and increased cytoplasmic localization, when compared to normal tissues [143, 147–150].
Gene_expression (overexpression) of HuR in colon associated with ovarian cancer
6) Confidence 0.35 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.06 Pain Relevance 0.03
Cytoplasmic but not nuclear HuR expression is significantly associated with tumor grade, poor differentiation, and lymph node metastasis in non-small cell lung cancer with increased levels of VEGF-C [154].
Gene_expression (expression) of HuR in lymph node associated with lung cancer, cancer and metastasis
7) Confidence 0.35 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.35 Pain Relevance 0
Elevated HuR expression occurs with the loss of TTP expression at an early stage of colorectal tumorigenesis that is associated with increased COX-2 expression [71].
Gene_expression (expression) of HuR
8) Confidence 0.35 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.80 Pain Relevance 0.19
Cytoplasmic expression of HuR is increased in urethane-induced neoplasia and in butylated hydroxytoluene-induced compensatory hyperplasia in mouse lung tissue [152].
Gene_expression (expression) of HuR in lung associated with cancer and hyperplasia
9) Confidence 0.35 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.27 Pain Relevance 0
Several studies have pointed out that HuR is overexpressed in tumor cells when compared to their normal counterparts, with increased localization of HuR in cytoplasmic compartments.
Gene_expression (overexpressed) of HuR associated with cancer
10) Confidence 0.35 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.85 Pain Relevance 0.03
The highly invasive breast cancer cell line, MDA-MB-231, which has increased constitutive levels of uPA, is due to impairment in the ARE-mediated decay of uPA mRNA; this is correlated with HuR overexpression and p38 MAP kinase induction [113].
Gene_expression (overexpression) of HuR in MDA-MB-231 associated with breast cancer
11) Confidence 0.35 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.10 Pain Relevance 0.06
Alternations in the cellular localization and expression of HuR
Gene_expression (expression) of HuR
12) Confidence 0.35 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.84 Pain Relevance 0.15
It is associated with increased HuR expression in different types of cancers; for example, major HuR expression is detected in perinecrotic areas in which VEGF, COX-2, and IL-8, all angiogenesis factors, are up-regulated [151].
Gene_expression (expression) of HuR associated with cancer
13) Confidence 0.31 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.22 Pain Relevance 0
CUGBP2 can override HuR and suppresses COX-2 mRNA translation [95].
Gene_expression (override) of HuR
14) Confidence 0.31 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.52 Pain Relevance 0.20
How is cytoplasmic localization of HuR promoted in tumor cells?
Gene_expression (promoted) of HuR associated with cancer
15) Confidence 0.31 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.02 Pain Relevance 0.08
Overexpression of RNA-binding protein that tends to stabilize AU-rich mRNAs such as HuR and certain isoforms of AUF1 is observed in certain cancers.
Gene_expression (Overexpression) of HuR associated with cancer
16) Confidence 0.31 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.13 Pain Relevance 0.22
Overexpression and cytoplasmic localization of stabilizing ARE binding proteins, notably HuR, with commitment functional loss of RNA decay-promoting proteins such as TTP can be associated with chronic inflammation and cancer.
Gene_expression (Overexpression) of HuR associated with inflammation and cancer
17) Confidence 0.31 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.30 Pain Relevance 0.17
HuR overexpression and cytoplasmic localization leads to binding to, and upregulation of, COX-2 mRNA expression in a number of cancers [71, 156–159].
Gene_expression (overexpression) of HuR associated with cancer
18) Confidence 0.31 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.30 Pain Relevance 0
is constitutively overexpressed in several cancers as a result of hypoxia, it also increases ARE-mRNA stability of VEGF [23] in a manner that is associated with HuR expression and cytoplasmic localization.
Gene_expression (expression) of HuR associated with hypoxia and cancer
19) Confidence 0.28 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.98 Pain Relevance 0

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