INT149649

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 3.59
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hnrnpd) RNA binding (Hnrnpd) nucleus (Hnrnpd)
DNA binding (Hnrnpd) cytoplasm (Hnrnpd)
Anatomy Link Frequency
poly 1
Hnrnpd (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 580 98.96 Very High Very High Very High
Inflammatory stimuli 15 93.68 High High
Clonidine 3 93.44 High High
cytokine 165 85.16 High High
Pain management 1 82.20 Quite High
anesthesia 1 81.04 Quite High
Inflammatory response 21 76.92 Quite High
cINOD 25 19.20 Low Low
chemokine 50 5.00 Very Low Very Low Very Low
Arthritis 25 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 601 98.96 Very High Very High Very High
Cancer 720 98.28 Very High Very High Very High
Pain 1 81.76 Quite High
Sleep Disorders 1 81.40 Quite High
Hypertension 1 79.24 Quite High
Targeted Disruption 30 78.64 Quite High
Sepsis 1 77.48 Quite High
Bacterial Infection 5 75.28 Quite High
Congenital Anomalies 10 74.08 Quite High
Shock 5 58.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The RNA-binding stabilizing protein, HuR, is able to compete with the RNA-binding proteins such as TTP and AUF1 for the same mRNA targets; however, it can also act independently on mRNA targets for promoting mRNA stabilization
AUF1 Binding (binding) of
1) Confidence 0.14 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.93 Pain Relevance 0.28
Tristetraprolin and several other RNA-binding proteins such as BRF1, KSRP, and AUF1 appear to function by targeting AU-rich mRNA to the exosome, a multiprotein complex with 3?
AUF1 Binding (binding) of
2) Confidence 0.14 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.05 Pain Relevance 0.04
Associations of KSRP and AUF1 p45, or KSRP and HuR, allow fine tuning of ARE-mRNA stability [93, 94].
AUF1 p45 Binding (Associations) of
3) Confidence 0.11 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.35 Pain Relevance 0.14
The RNA-binding stabilizing protein, HuR, is able to compete with the RNA-binding proteins such as TTP and AUF1 for the same mRNA targets; however, it can also act independently on mRNA targets for promoting mRNA stabilization
AUF1 Binding (binding) of
4) Confidence 0.11 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.93 Pain Relevance 0.28
Stability of iNOS mRNA is regulated by RNA stabilizing factor, e.g., Hu antigen R (HuR), and RNA destabilizing factors, e.g., AU-rich element/poly(U) binding factor-1 (AUF-1) and tristetraprolin (TTP).
AUF-1 Binding (binding) of in poly
5) Confidence 0.11 Published 2008 Journal J. Surg. Res. Section Abstract Doc Link 18262561 Disease Relevance 0.40 Pain Relevance 0.45
AUF1 binds to and destabilizes both inflammation and cancer-associated ARE-mRNAs such as c-myc, TNF-?
AUF1 Binding (binds) of associated with inflammation and cancer
6) Confidence 0.11 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.92 Pain Relevance 0.25

General Comments

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