INT149656

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Context Info
Confidence 0.38
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.36
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc12a2)
Slc12a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anticonvulsant 5 97.04 Very High Very High Very High
Inflammation 8 96.60 Very High Very High Very High
Spinal cord 6 95.40 Very High Very High Very High
IPN 2 89.16 High High
Hyperalgesia 2 84.12 Quite High
intrathecal 1 84.00 Quite High
allodynia 1 83.44 Quite High
gABA 36 77.36 Quite High
Stimulus evoked pain 1 75.00 Quite High
Dorsal horn neuron 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 3 99.48 Very High Very High Very High
Chronic Renal Failure 248 99.20 Very High Very High Very High
INFLAMMATION 5 96.60 Very High Very High Very High
Inflammatory Pain 3 89.16 High High
Neuropathic Pain 3 85.20 High High
Hyperalgesia 2 84.12 Quite High
Convulsion 30 78.44 Quite High
Hypersensitivity 2 75.00 Quite High
Syndrome 1 60.40 Quite High
Epilepsy 22 59.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results suggest that the expression of KCC2, but not that of NKCC1, was significantly reduced in CFA-injected rats.
Negative_regulation (reduced) of Gene_expression (expression) of NKCC1
1) Confidence 0.38 Published 2008 Journal Neuroscience Section Abstract Doc Link 18262726 Disease Relevance 0.95 Pain Relevance 0.86
Its efficacy dropped though in older ages, probably due to the decreased expression of NKCC1.
Negative_regulation (decreased) of Gene_expression (expression) of NKCC1
2) Confidence 0.21 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0.54 Pain Relevance 0.17
In contrast, mice lacking NHE3 showed decreased expression of BSC-1 and sodium wasting (33), however they also had decreased SNGFR in contrast to CRF (34).
Negative_regulation (decreased) of Gene_expression (expression) of BSC-1 associated with chronic renal failure
3) Confidence 0.12 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.43 Pain Relevance 0
The observed decrease in BSC-1 abundance in the NHE3 knockout mice is unexplained based on current knowledge regarding the regulation of these transporters and further investigation is needed to address this.



Negative_regulation (decrease) of Gene_expression (abundance) of BSC-1 associated with targeted disruption
4) Confidence 0.07 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.43 Pain Relevance 0

General Comments

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