INT149680

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Context Info
Confidence 0.53
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Parp1) nuclear envelope (Parp1) protein complex (Parp1)
signal transducer activity (Oprm1) signal transduction (Oprm1) nucleolus (Parp1)
Anatomy Link Frequency
poly 3
Parp1 (Mus musculus)
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 39 100.00 Very High Very High Very High
Morphine 6 91.32 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we report that poly(ADP-ribose) polymerase 1 (PARP-1) binds to the double-stranded poly(C) element essential for the MOR promoter and represses promoter activity at the transcriptional level.
PARP-1 Binding (binds) of MOR promoter in poly associated with mu opioid receptor
1) Confidence 0.53 Published 2008 Journal J. Cell. Mol. Med. Section Abstract Doc Link 18266974 Disease Relevance 0 Pain Relevance 0.46
PARP-1 binding to the poly(C) sequence of the MOR gene was sequence-specific as confirmed by the supershift assay.
PARP-1 Binding (binding) of MOR gene in poly associated with mu opioid receptor
2) Confidence 0.53 Published 2008 Journal J. Cell. Mol. Med. Section Abstract Doc Link 18266974 Disease Relevance 0 Pain Relevance 0.54
Chromatin immunoprecipitation assays showed specific binding of PARP-1 to the double-stranded poly(C) element essential for the MOR promoter.
PARP-1 Binding (binding) of MOR promoter in poly associated with mu opioid receptor
3) Confidence 0.39 Published 2008 Journal J. Cell. Mol. Med. Section Abstract Doc Link 18266974 Disease Relevance 0 Pain Relevance 0.65

General Comments

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