INT149689

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Context Info
Confidence 0.24
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.54
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrm3) plasma membrane (Chrm3) signal transducer activity (Chrm3)
Anatomy Link Frequency
ileum 2
bladder 2
liver 1
Chrm3 (Mus musculus)
Pain Link Frequency Relevance Heat
licofelone 7 98.12 Very High Very High Very High
antagonist 65 96.52 Very High Very High Very High
abdominal pain 2 83.72 Quite High
nud 4 76.12 Quite High
adenocard 3 56.08 Quite High
Potency 48 50.00 Quite Low
Osteoarthritis 1 48.84 Quite Low
agonist 33 43.64 Quite Low
cOX1 1 25.00 Low Low
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Overactive Bladder 59 98.12 Very High Very High Very High
Targeted Disruption 189 91.72 High High
Abdominal Pain 2 83.72 Quite High
Dyspepsia 4 76.12 Quite High
Constipation 11 74.12 Quite High
Xerostomia 15 73.12 Quite High
Osteoarthritis 1 48.84 Quite Low
Peripheral Arterial Disease 1 35.32 Quite Low
Incontinence 23 34.96 Quite Low
Urge Incontinence 4 20.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the M3 antagonism profile of standard muscarinic contractions of the ileum and bladder is not inconsistent with the postulate that both M2 and M3 receptors interact to elicit contraction.
M3 Binding (interact) of in bladder
1) Confidence 0.24 Published 2009 Journal Naunyn Schmiedebergs Arch Pharmacol Section Body Doc Link PMC2749929 Disease Relevance 0.22 Pain Relevance 0.03
These results are summarized in TableĀ 3 and are consistent with the postulate mentioned above that the muscarinic contractile response in the mouse ileum includes major and minor, directly acting M3 and M2 components, respectively.
M3 Binding (acting) of in ileum
2) Confidence 0.21 Published 2009 Journal Naunyn Schmiedebergs Arch Pharmacol Section Body Doc Link PMC2749929 Disease Relevance 0.59 Pain Relevance 0
Thus, the M3 antagonism profile of standard muscarinic contractions of the ileum and bladder is not inconsistent with the postulate that both M2 and M3 receptors interact to elicit contraction.
M3 Binding (interact) of in ileum
3) Confidence 0.08 Published 2009 Journal Naunyn Schmiedebergs Arch Pharmacol Section Body Doc Link PMC2749929 Disease Relevance 0.22 Pain Relevance 0.03
The formation of M3 was also observed with liver microsomes from cynomolgus monkeys, but in incubations with mouse and rat liver microsomes, M1 remained unchanged.
M3 Binding (formation) of in liver
4) Confidence 0.04 Published 2008 Journal Drug Metab. Dispos. Section Abstract Doc Link 18268076 Disease Relevance 0 Pain Relevance 0.43
It has a greater affinity for the bladder-specific M3 receptor.
M3 Binding (affinity) of in bladder
5) Confidence 0.02 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2685261 Disease Relevance 0.53 Pain Relevance 0.17

General Comments

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