INT149698

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Context Info
Confidence 0.15
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.21
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd28)
Anatomy Link Frequency
T cells 2
Cd28 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 27 99.84 Very High Very High Very High
abatacept 6 97.96 Very High Very High Very High
cytokine 3 80.92 Quite High
Arthritis 3 58.88 Quite High
anakinra 1 35.00 Quite Low
Inflammation 5 18.52 Low Low
methotrexate 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 27 99.84 Very High Very High Very High
Disease 14 85.88 High High
Autoimmune Disease 4 75.00 Quite High
Organ Transplantation 1 60.16 Quite High
Arthritis 3 58.88 Quite High
INFLAMMATION 5 18.52 Low Low
Synovitis 2 9.92 Low Low
Congenital Anomalies 1 9.08 Low Low
Necrosis 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The selective costimulation inhibitor abatacept (cytotoxic T lymphocyte-associated antigen 4-Ig) binds to CD80 and CD86 on antigen-presenting cells, blocking interaction with CD28 on T cells, and is approved for the treatment of moderate to severe rheumatoid arthritis.
Negative_regulation (blocking) of CD28 Binding (interaction) of in T cells associated with rheumatoid arthritis and abatacept
1) Confidence 0.15 Published 2008 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 18269922 Disease Relevance 0.35 Pain Relevance 0.28
The detailed consequences of blocking the interaction between CD80/86 and CD28 in RA still require study, in particular because co-stimulatory pathways other than CD28-mediated ones remain unaffected.
Negative_regulation (blocking) of CD28 Binding (interaction) of associated with rheumatoid arthritis
2) Confidence 0.02 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833982 Disease Relevance 0.87 Pain Relevance 0.47

General Comments

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