INT1497

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Context Info
Confidence 0.59
First Reported 1978
Last Reported 2010
Negated 8
Speculated 10
Reported most in Abstract
Documents 415
Total Number 428
Disease Relevance 192.95
Pain Relevance 74.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh) signal transduction (Gh) mitochondrion (Gh)
extracellular space (Gh) extracellular region (Gh) plasma membrane (Gh)
Anatomy Link Frequency
plasma 26
pituitary 26
body 7
blood 6
anterior pituitary 4
Gh (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 537 100.00 Very High Very High Very High
carpal tunnel syndrome 50 100.00 Very High Very High Very High
Somatostatin 1859 99.98 Very High Very High Very High
narcan 122 99.98 Very High Very High Very High
Pain 220 99.96 Very High Very High Very High
GABAergic 29 99.96 Very High Very High Very High
Dismenorea 4 99.88 Very High Very High Very High
headache 215 99.84 Very High Very High Very High
noradrenaline 19 99.82 Very High Very High Very High
agonist 337 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acromegaly 2060 100.00 Very High Very High Very High
Cancer 1727 100.00 Very High Very High Very High
Syndrome 859 100.00 Very High Very High Very High
Carcinoid 507 100.00 Very High Very High Very High
Growth Hormone Deficiency 208 100.00 Very High Very High Very High
Pressure And Volume Under Development 194 100.00 Very High Very High Very High
Sleep Disorders 97 100.00 Very High Very High Very High
Carpal Tunnel Syndrome 50 100.00 Very High Very High Very High
Adenoma 446 99.96 Very High Very High Very High
Growth Problems 176 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In several aspects the features of aging resemble those of the state of growth hormone (GH) deficiency.
Negative_regulation (deficiency) of growth hormone associated with aging
1) Confidence 0.59 Published 1997 Journal Calcif. Tissue Int. Section Abstract Doc Link 9192516 Disease Relevance 0.60 Pain Relevance 0.19
In several aspects the features of aging resemble those of the state of growth hormone (GH) deficiency.
Negative_regulation (deficiency) of GH associated with aging
2) Confidence 0.59 Published 1997 Journal Calcif. Tissue Int. Section Abstract Doc Link 9192516 Disease Relevance 0.60 Pain Relevance 0.19
Suppression of normal and preneoplastic mammary growth and uterine adenomyosis with reduced growth hormone level in SHN mice given monosodium glutamate neonatally.
Negative_regulation (reduced) of growth hormone in uterine associated with glutamate and dismenorea
3) Confidence 0.58 Published 1985 Journal Eur J Cancer Clin Oncol Section Title Doc Link 3830732 Disease Relevance 0.33 Pain Relevance 0.55
Within eight months of therapy, basal growth hormone (GH) levels decreased from 90.0 to 7.0 ng/mL, and hand volume was reduced from 375 to 295 mL.
Negative_regulation (decreased) of GH
4) Confidence 0.58 Published 1980 Journal JAMA Section Abstract Doc Link 7420685 Disease Relevance 0.51 Pain Relevance 0.28
Growth hormone (GH) deficiency had been detected in 6 children and 5 had received GH replacement, for a minimum of more than 3 years. 9 children were radiographically osteopenic (including the 5 who had received GH).
Negative_regulation (deficiency) of GH
5) Confidence 0.58 Published 1998 Journal Eur. J. Cancer Section Abstract Doc Link 9797700 Disease Relevance 0.77 Pain Relevance 0.20
Growth hormone (GH) deficiency had been detected in 6 children and 5 had received GH replacement, for a minimum of more than 3 years. 9 children were radiographically osteopenic (including the 5 who had received GH).
Negative_regulation (deficiency) of Growth hormone
6) Confidence 0.58 Published 1998 Journal Eur. J. Cancer Section Abstract Doc Link 9797700 Disease Relevance 0.77 Pain Relevance 0.20
Within eight months of therapy, basal growth hormone (GH) levels decreased from 90.0 to 7.0 ng/mL, and hand volume was reduced from 375 to 295 mL.
Negative_regulation (decreased) of growth hormone
7) Confidence 0.58 Published 1980 Journal JAMA Section Abstract Doc Link 7420685 Disease Relevance 0.51 Pain Relevance 0.28
A specific action of bromocriptine on the degradation rate of 'little' GH may result in a selective reduction of the bioactive monomeric component of GH and may explain the discrepancy between the clinical and the biochemical response to bromocriptine.
Negative_regulation (reduction) of GH
8) Confidence 0.58 Published 1980 Journal Horm. Res. Section Abstract Doc Link 7390405 Disease Relevance 0.67 Pain Relevance 0.12
In the postoperative assays, a 73% or greater suppression of GH levels correlated with significant clinical remission and extended survival.
Negative_regulation (suppression) of GH
9) Confidence 0.58 Published 1982 Journal J Med Section Abstract Doc Link 6184430 Disease Relevance 0.51 Pain Relevance 0.33
In all patients who had as much as 73% reduction in GH level, pain relief occurred within 4 days or less after surgery.
Negative_regulation (reduction) of GH associated with pain
10) Confidence 0.58 Published 1982 Journal J Med Section Abstract Doc Link 6184430 Disease Relevance 0.50 Pain Relevance 0.34
RESULTS: Three of our children were diagnosed with isolated hormone abnormalities (2 children with precocious puberty and 1 child with growth hormone, GH deficiency).
Negative_regulation (deficiency) of GH
11) Confidence 0.57 Published 1999 Journal Pediatr Neurosurg Section Body Doc Link 10702732 Disease Relevance 0 Pain Relevance 0
In the 12 patients with idiopathic GH deficiency the course of IH was benign, with complete resolution of all signs and symptoms.
Negative_regulation (deficiency) of GH associated with cva
12) Confidence 0.57 Published 1995 Journal J. Pediatr. Section Abstract Doc Link 7776116 Disease Relevance 1.09 Pain Relevance 0.34
Benign intracranial hypertension in children with growth hormone deficiency treated with growth hormone.
Negative_regulation (deficiency) of growth hormone associated with cva, growth hormone deficiency and pseudotumor cerebri
13) Confidence 0.57 Published 1995 Journal J. Pediatr. Section Title Doc Link 7776116 Disease Relevance 0.99 Pain Relevance 0.31
However, there is no clear consensus on the appropriate length of time over which serial blood samples for GH should be obtained for diagnosing GH deficiency.
Negative_regulation (deficiency) of GH in blood
14) Confidence 0.57 Published 2001 Journal J. Pediatr. Endocrinol. Metab. Section Abstract Doc Link 11795657 Disease Relevance 0 Pain Relevance 0.37
Headaches, especially in the first few months of therapy, require close evaluation as benign intracranial hypertension is found infrequently, especially in children with GH deficiency and chronic renal failure (CRF).
Negative_regulation (deficiency) of GH associated with chronic renal failure, cva, headache and pseudotumor cerebri
15) Confidence 0.56 Published 2000 Journal Growth Horm. IGF Res. Section Abstract Doc Link 11161961 Disease Relevance 0.66 Pain Relevance 0.15
Decreases in growth hormone (GH) and insulin-like growth factor I occur with age, in addition to oestrogen deficiency in women and a reduction in the levels of testosterone in men.
Negative_regulation (Decreases) of GH
16) Confidence 0.56 Published 2003 Journal Horm. Res. Section Abstract Doc Link 12955028 Disease Relevance 0 Pain Relevance 0
Decreases in growth hormone (GH) and insulin-like growth factor I occur with age, in addition to oestrogen deficiency in women and a reduction in the levels of testosterone in men.
Negative_regulation (Decreases) of growth hormone
17) Confidence 0.56 Published 2003 Journal Horm. Res. Section Abstract Doc Link 12955028 Disease Relevance 0 Pain Relevance 0
In the bromocriptine test, octreotide had a synergistic effect on the suppression of GH.
Negative_regulation (suppression) of GH
18) Confidence 0.56 Published 1992 Journal J. Formos. Med. Assoc. Section Abstract Doc Link 1358345 Disease Relevance 0.53 Pain Relevance 0.24
GH levels of less than 7 ng/ml in children not suffering from protein malnutrition suggest total GH deficiency.
Negative_regulation (deficiency) of GH associated with appetite loss
19) Confidence 0.55 Published 1991 Journal Indian J Pediatr Section Abstract Doc Link 1824377 Disease Relevance 0.57 Pain Relevance 0.15
Concomitant treatment of animals with the beta-adrenergic antagonist propranolol completely blocked the noradrenaline-induced suppression of GH.
Negative_regulation (suppression) of GH associated with antagonist and noradrenaline
20) Confidence 0.55 Published 1994 Journal Domest. Anim. Endocrinol. Section Abstract Doc Link 8045100 Disease Relevance 0 Pain Relevance 0.36

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